TY - JOUR
T1 - High-carbohydrate/low-protein-induced hyperinsulinemia does not improve protein balance in children after cardiac surgery
AU - Geukers, Vincent G.
AU - Li, Zhihao
AU - Ackermans, Mariëtte T.
AU - Bos, Albert P.
AU - Jinfeng, Liu
AU - Sauerwein, Hans P.
PY - 2012
Y1 - 2012
N2 - Objective: In pediatric cardiac surgery, fluid-restricted low-protein (LoProt) diets account for cumulative protein deficits with increased morbidity. In this setting, we aimed to inhibit proteolysis by a high-carbohydrate (HiCarb)-intake-induced hyperinsulinemia and improve protein balance. Methods: The effect of a HiCarb/LoProt (glucose 10 mg . kg(-1) . min(-1)/protein 0.7 g . kg(-1) . d(-1)) versus a normal-carbohydrate (NormCarb)/LoProt (glucose 7.5 mg . kg(-1) . min(-1)/protein 0.3g . kg(-1) . d(-1)) enteral diet on whole-body protein breakdown and balance was compared in a prospective, randomized, single-blinded trial in 24 children after cardiac surgery. On the second postoperative day, plasma insulin and amino acid concentrations, protein breakdown (endogenous rate of appearance of valine), protein synthesis (non-oxidative disposal of valine), protein balance, and the rate of appearance of urea were measured by using an isotopic infusion of [1-C-13]valine and [N-15(2)] urea. Results: The HiCarb/LoProt diet led to a serum insulin concentration that was three times higher than the NormCarb/LoProt diet (596 pmol/L, 80-1833, and 198 pmol/L, 76-1292, respectively, P = 0.02), without differences in plasma glucose concentrations. There were no differences in plasma amino acid concentrations, non-oxidative disposal of valine, and endogenous rate of appearance of valine between the groups, with a negative valine balance in the two groups (-0.65 mu mol . kg(-1) min(-1), -1.91 to 0.01, and -0.58 mu mol . kg(-1) . min(-1), -2.32 to -0.07, respectively, P = 0.71). The serum cortisol concentration in the HiCarb/LoProt group was lower compared with the NormCarb/LoProt group (204 nmol/L, 50-544, and 532 nmol/L, 108-930, respectively, P = 0.02). Conclusion: In children with fluid restriction after cardiac surgery, a HiCarb/LoProt diet compared with a NormCarb/LoProt diet stimulates insulin secretion but does not inhibit proteolysis further and therefore cannot be advocated for this purpose. (C) 2012 Elsevier Inc. All rights reserved
AB - Objective: In pediatric cardiac surgery, fluid-restricted low-protein (LoProt) diets account for cumulative protein deficits with increased morbidity. In this setting, we aimed to inhibit proteolysis by a high-carbohydrate (HiCarb)-intake-induced hyperinsulinemia and improve protein balance. Methods: The effect of a HiCarb/LoProt (glucose 10 mg . kg(-1) . min(-1)/protein 0.7 g . kg(-1) . d(-1)) versus a normal-carbohydrate (NormCarb)/LoProt (glucose 7.5 mg . kg(-1) . min(-1)/protein 0.3g . kg(-1) . d(-1)) enteral diet on whole-body protein breakdown and balance was compared in a prospective, randomized, single-blinded trial in 24 children after cardiac surgery. On the second postoperative day, plasma insulin and amino acid concentrations, protein breakdown (endogenous rate of appearance of valine), protein synthesis (non-oxidative disposal of valine), protein balance, and the rate of appearance of urea were measured by using an isotopic infusion of [1-C-13]valine and [N-15(2)] urea. Results: The HiCarb/LoProt diet led to a serum insulin concentration that was three times higher than the NormCarb/LoProt diet (596 pmol/L, 80-1833, and 198 pmol/L, 76-1292, respectively, P = 0.02), without differences in plasma glucose concentrations. There were no differences in plasma amino acid concentrations, non-oxidative disposal of valine, and endogenous rate of appearance of valine between the groups, with a negative valine balance in the two groups (-0.65 mu mol . kg(-1) min(-1), -1.91 to 0.01, and -0.58 mu mol . kg(-1) . min(-1), -2.32 to -0.07, respectively, P = 0.71). The serum cortisol concentration in the HiCarb/LoProt group was lower compared with the NormCarb/LoProt group (204 nmol/L, 50-544, and 532 nmol/L, 108-930, respectively, P = 0.02). Conclusion: In children with fluid restriction after cardiac surgery, a HiCarb/LoProt diet compared with a NormCarb/LoProt diet stimulates insulin secretion but does not inhibit proteolysis further and therefore cannot be advocated for this purpose. (C) 2012 Elsevier Inc. All rights reserved
U2 - https://doi.org/10.1016/j.nut.2011.09.018
DO - https://doi.org/10.1016/j.nut.2011.09.018
M3 - Article
C2 - 22261573
SN - 0899-9007
VL - 28
SP - 644
EP - 650
JO - Nutrition (Burbank, Los Angeles County, Calif.)
JF - Nutrition (Burbank, Los Angeles County, Calif.)
IS - 6
ER -