High class II-associated invariant chain peptide expression on residual leukemic cells is associated with increased relapse risk in acute myeloid leukemia

Willemijn van den Ancker, Marvin M. van Luijn, Martine E. D. Chamuleau, Angèle Kelder, Nicole Feller, Monique Terwijn, Adri Zevenbergen, Gerrit-Jan Schuurhuis, S. Marieke van Ham, Theresia M. Westers, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht

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The presence of class II-associated invariant chain (CLIP) on leukemic cells is negatively associated with clinical outcome in untreated acute myeloid leukemia (AML). CLIP plays a role in the immune escape of leukemic cells, suggesting that it impairs the immunogenicity of minimal residual disease (MRD) cells causing a relapse. Here, we demonstrate that CLIP expression on leukemia-associated phenotype (LAP)-positive cells during follow-up is significantly correlated with a shortened relapse-free survival, even in those patients who are generally considered as MRD(low) (0.01-0.1% LAP(+) cells). Consequently, CLIP evaluation could be of additional value in the evaluation of MRD to predict a relapse of AML
Original languageEnglish
Pages (from-to)691-693
JournalLeukemia research
Issue number6
Publication statusPublished - 2014

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