TY - JOUR
T1 - High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty
T2 - the Longitudinal Aging Study Amsterdam
AU - Machado-Fragua, Marcos D.
AU - Hoogendijk, Emiel O.
AU - Struijk, Ellen A.
AU - Rodriguez-Artalejo, Fernando
AU - Lopez-Garcia, Esther
AU - Beulens, Joline W.
AU - van Ballegooijen, Adriana J.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Purpose: No previous study has evaluated the relationship between vitamin K and frailty. Thus, we assessed the relationship between vitamin K status and frailty over 13 years in the Longitudinal Aging Study Amsterdam (LASA). Methods: Prospective cohort study with 644 community-dwelling adults ≥ 55 years from the LASA cohort. In 2002–2003, plasma desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) was measured as marker of vitamin K status through a sandwich ELISA. Frailty was measured at baseline and in four follow-up examinations with the LASA Frailty Index (LASA-FI), which was used as both a continuous and a dichotomous measure (FI ≥ 0.25), as indicator of the degree of frailty and frailty risk, respectively. Statistical analyses were performed with multivariable generalized estimating equations using the lowest dp-ucMGP tertile, reflecting a high vitamin K status, as reference. Results: The mean (SD) age was 59.9 (2.9) years, and 54% were female. Compared with the lowest tertile, the medium and highest dp-ucMGP tertile were associated with a higher degree of frailty [1.40, 95% confidence interval (0.01–2.81) and 1.62, (0.18–3.06), respectively. P trend: 0.03]. Additionally, the medium and highest dp-ucMGP tertile had a higher odds ratio of frailty [1.75 (1.11–2.77) and 1.63 (1.04–2.57), respectively]. The degree of frailty increased over time, but the differences by dp-ucMGP tertiles existed since baseline and remained stable during follow-up. Conclusions: Baseline plasma low vitamin K status was associated with a greater degree of frailty and frailty risk in this cohort of older adults, which highlights the importance of ensuring an optimal nutritional status of this vitamin to prevent frailty in later life.
AB - Purpose: No previous study has evaluated the relationship between vitamin K and frailty. Thus, we assessed the relationship between vitamin K status and frailty over 13 years in the Longitudinal Aging Study Amsterdam (LASA). Methods: Prospective cohort study with 644 community-dwelling adults ≥ 55 years from the LASA cohort. In 2002–2003, plasma desphospho-uncarboxylated matrix Gla protein (dp-ucMGP) was measured as marker of vitamin K status through a sandwich ELISA. Frailty was measured at baseline and in four follow-up examinations with the LASA Frailty Index (LASA-FI), which was used as both a continuous and a dichotomous measure (FI ≥ 0.25), as indicator of the degree of frailty and frailty risk, respectively. Statistical analyses were performed with multivariable generalized estimating equations using the lowest dp-ucMGP tertile, reflecting a high vitamin K status, as reference. Results: The mean (SD) age was 59.9 (2.9) years, and 54% were female. Compared with the lowest tertile, the medium and highest dp-ucMGP tertile were associated with a higher degree of frailty [1.40, 95% confidence interval (0.01–2.81) and 1.62, (0.18–3.06), respectively. P trend: 0.03]. Additionally, the medium and highest dp-ucMGP tertile had a higher odds ratio of frailty [1.75 (1.11–2.77) and 1.63 (1.04–2.57), respectively]. The degree of frailty increased over time, but the differences by dp-ucMGP tertiles existed since baseline and remained stable during follow-up. Conclusions: Baseline plasma low vitamin K status was associated with a greater degree of frailty and frailty risk in this cohort of older adults, which highlights the importance of ensuring an optimal nutritional status of this vitamin to prevent frailty in later life.
KW - Epidemiology
KW - Frailty
KW - Frailty index
KW - Matrix Gla protein
KW - Older adults
KW - Vitamin k
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85065564024&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31069456
U2 - https://doi.org/10.1007/s00394-019-01984-9
DO - https://doi.org/10.1007/s00394-019-01984-9
M3 - Article
C2 - 31069456
SN - 1436-6207
VL - 59
SP - 1243
EP - 1251
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 3
ER -