High-Fat Diet Impacts on Tumor Development in the Gut

Milou S. van Driel; Sanne M. van Neerven; Louis Vermeulen

doi:https://doi.org/10.1016/j.trecan.2021.06.005

High-Fat Diet Impacts on Tumor Development in the Gut

Milou S. van Driel, Sanne M. van Neerven, Louis Vermeulen

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

A high-fat diet (HFD) directly acts on intestinal stem cells by increasing their numbers and proliferation, resulting in an elevated risk of developing colorectal cancer (CRC). In a recent study, Mana et al. revealed that HFD-mediated intestinal tumor formation can be reduced by inhibiting fatty acid oxidation.

Original language	English
Pages (from-to)	664-665
Number of pages	2
Journal	Trends in Cancer
Volume	7
Issue number	8
DOIs	https://doi.org/10.1016/j.trecan.2021.06.005
Publication status	Published - 1 Aug 2021

Keywords

PPARs
colorectal cancer
high-fat diet
intestinal stem cells
tumor initiation

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https://doi.org/10.1016/j.trecan.2021.06.005

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title = "High-Fat Diet Impacts on Tumor Development in the Gut",

abstract = "A high-fat diet (HFD) directly acts on intestinal stem cells by increasing their numbers and proliferation, resulting in an elevated risk of developing colorectal cancer (CRC). In a recent study, Mana et al. revealed that HFD-mediated intestinal tumor formation can be reduced by inhibiting fatty acid oxidation.",

keywords = "PPARs, colorectal cancer, high-fat diet, intestinal stem cells, tumor initiation",

author = "{van Driel}, {Milou S.} and {van Neerven}, {Sanne M.} and Louis Vermeulen",

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AU - van Driel, Milou S.

AU - van Neerven, Sanne M.

AU - Vermeulen, Louis

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N2 - A high-fat diet (HFD) directly acts on intestinal stem cells by increasing their numbers and proliferation, resulting in an elevated risk of developing colorectal cancer (CRC). In a recent study, Mana et al. revealed that HFD-mediated intestinal tumor formation can be reduced by inhibiting fatty acid oxidation.

AB - A high-fat diet (HFD) directly acts on intestinal stem cells by increasing their numbers and proliferation, resulting in an elevated risk of developing colorectal cancer (CRC). In a recent study, Mana et al. revealed that HFD-mediated intestinal tumor formation can be reduced by inhibiting fatty acid oxidation.

KW - PPARs

KW - colorectal cancer

KW - high-fat diet

KW - intestinal stem cells

KW - tumor initiation

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JO - Trends in Cancer

JF - Trends in Cancer

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High-Fat Diet Impacts on Tumor Development in the Gut

Abstract

Keywords

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