TY - JOUR
T1 - High plasma cholesteryl ester transfer but not CETP mass predicts incident cardiovascular disease: a nested case-control study
AU - Kappelle, Paul J. W. H.
AU - Perton, Frank
AU - Hillege, Hans L.
AU - Dallinga-Thie, Geesje M.
AU - Dullaart, Robin P. F.
PY - 2011
Y1 - 2011
N2 - The relationship of cardiovascular disease (CVD) with plasma cholesteryl ester transfer protein (CETP) levels is controversial. We determined whether plasma cholesteryl ester transfer (CET), reflecting CETP-mediated transfer of cholesteryl esters from endogenous HDL towards apolipoprotein B-lipoproteins, predicts incident CVD. A prospective nested case-control study was carried out in 114 men who developed CVD and 105 controls. Participants did not use lipid lowering drugs at baseline. Plasma CET was assayed using an isotope method. Plasma CET was 19% higher (P=0.030), whereas CETP mass was unaltered (P=0.30) in cases vs. controls. Plasma CET predicted CVD (age-adjusted hazard ratio (HR): 1.20 (95% CI 1.02-1.46, P=0.028), but incident CVD was unrelated to CETP mass (HR: 0.88 (95% CI 0.73-1.07), P=0.20). Plasma CET still predicted CVD after additional adjustment for total cholesterol/HDL cholesterol, triglycerides and non-lipid risk markers (HR: 1.22 (95% CI 1.02-1.46, P=0.031). Plasma CET rather than CETP mass may be a determinant of cardiovascular risk
AB - The relationship of cardiovascular disease (CVD) with plasma cholesteryl ester transfer protein (CETP) levels is controversial. We determined whether plasma cholesteryl ester transfer (CET), reflecting CETP-mediated transfer of cholesteryl esters from endogenous HDL towards apolipoprotein B-lipoproteins, predicts incident CVD. A prospective nested case-control study was carried out in 114 men who developed CVD and 105 controls. Participants did not use lipid lowering drugs at baseline. Plasma CET was assayed using an isotope method. Plasma CET was 19% higher (P=0.030), whereas CETP mass was unaltered (P=0.30) in cases vs. controls. Plasma CET predicted CVD (age-adjusted hazard ratio (HR): 1.20 (95% CI 1.02-1.46, P=0.028), but incident CVD was unrelated to CETP mass (HR: 0.88 (95% CI 0.73-1.07), P=0.20). Plasma CET still predicted CVD after additional adjustment for total cholesterol/HDL cholesterol, triglycerides and non-lipid risk markers (HR: 1.22 (95% CI 1.02-1.46, P=0.031). Plasma CET rather than CETP mass may be a determinant of cardiovascular risk
U2 - https://doi.org/10.1016/j.atherosclerosis.2011.03.020
DO - https://doi.org/10.1016/j.atherosclerosis.2011.03.020
M3 - Article
C2 - 21524747
SN - 0021-9150
VL - 217
SP - 249
EP - 252
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -