High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members

J. M. Hoovers, E. Redeker, F. Speleman, J. W. Höppener, S. Bhola, J. Bliek, N. van Roy, N. J. Leschot, A. Westerveld, M. Mannens

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Abstract

We report the high-resolution localization of the human calcitonin/CGRP genes, CALCA, CALCB, and the pseudogene CALCP, to a 220-kb SacII fragment on chromosome 11p15.2-p15.1, using prometaphase fluorescence in situ hybridization (FISH), two-color interphase FISH, and pulsed-field gel electrophoresis analysis. The related islet amyloid polypeptide (IAPP) gene was assigned to human chromosome 12p12.3-p12.1. The results support an evolutionary relationship between the calcitonin/CGRP genes and the IAPP gene and between parts of human chromosomes 11 and 12
Original languageEnglish
Pages (from-to)525-529
JournalGenomics
Volume15
Issue number3
DOIs
Publication statusPublished - 1993

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