High-resolution localization of 69 potential human zinc finger protein genes: a number are clustered

J. M. Hoovers; M. Mannens; R. John; J. Bliek; V. van Heyningen; D. J. Porteous; N. J. Leschot; A. Westerveld; P. F. Little

doi:https://doi.org/10.1016/0888-7543(92)90372-Y

High-resolution localization of 69 potential human zinc finger protein genes: a number are clustered

J. M. Hoovers, M. Mannens, R. John, J. Bliek, V. van Heyningen, D. J. Porteous, N. J. Leschot, A. Westerveld, P. F. Little

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Abstract

In this study, we describe the identification and partial characterization of 101 potential human zinc finger protein genes (ZnFPs). These sequences were isolated by hybridization of cosmids, obtained from mouse-human cell lines enriched for chromosome 11p, with an oligonucleotide specific for the "link" sequence between contiguous zinc fingers. Sixty-nine of these cosmids were regionally localized to human prometaphase chromosomes by in situ hybridization. The localization of these cosmids suggests that a number of finger protein genes occur in linked clusters. Their assignment to chromosomes 3p, 11p, 19p, 19qter, 20p, and 21q makes them valuable as markers or "candidate" genes for diseases associated with these chromosome regions

Original language	English
Pages (from-to)	254-263
Journal	Genomics
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0888-7543(92)90372-Y
Publication status	Published - 1992

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https://doi.org/10.1016/0888-7543(92)90372-Y

Cite this

@article{b95013cb7dd04d9a85abf05bbeafefb2,

title = "High-resolution localization of 69 potential human zinc finger protein genes: a number are clustered",

abstract = "In this study, we describe the identification and partial characterization of 101 potential human zinc finger protein genes (ZnFPs). These sequences were isolated by hybridization of cosmids, obtained from mouse-human cell lines enriched for chromosome 11p, with an oligonucleotide specific for the {"}link{"} sequence between contiguous zinc fingers. Sixty-nine of these cosmids were regionally localized to human prometaphase chromosomes by in situ hybridization. The localization of these cosmids suggests that a number of finger protein genes occur in linked clusters. Their assignment to chromosomes 3p, 11p, 19p, 19qter, 20p, and 21q makes them valuable as markers or {"}candidate{"} genes for diseases associated with these chromosome regions",

author = "Hoovers, {J. M.} and M. Mannens and R. John and J. Bliek and {van Heyningen}, V. and Porteous, {D. J.} and Leschot, {N. J.} and A. Westerveld and Little, {P. F.}",

year = "1992",

doi = "https://doi.org/10.1016/0888-7543(92)90372-Y",

language = "English",

volume = "12",

pages = "254--263",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

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T1 - High-resolution localization of 69 potential human zinc finger protein genes: a number are clustered

AU - Hoovers, J. M.

AU - Mannens, M.

AU - John, R.

AU - Bliek, J.

AU - van Heyningen, V.

AU - Porteous, D. J.

AU - Leschot, N. J.

AU - Westerveld, A.

AU - Little, P. F.

PY - 1992

Y1 - 1992

N2 - In this study, we describe the identification and partial characterization of 101 potential human zinc finger protein genes (ZnFPs). These sequences were isolated by hybridization of cosmids, obtained from mouse-human cell lines enriched for chromosome 11p, with an oligonucleotide specific for the "link" sequence between contiguous zinc fingers. Sixty-nine of these cosmids were regionally localized to human prometaphase chromosomes by in situ hybridization. The localization of these cosmids suggests that a number of finger protein genes occur in linked clusters. Their assignment to chromosomes 3p, 11p, 19p, 19qter, 20p, and 21q makes them valuable as markers or "candidate" genes for diseases associated with these chromosome regions

AB - In this study, we describe the identification and partial characterization of 101 potential human zinc finger protein genes (ZnFPs). These sequences were isolated by hybridization of cosmids, obtained from mouse-human cell lines enriched for chromosome 11p, with an oligonucleotide specific for the "link" sequence between contiguous zinc fingers. Sixty-nine of these cosmids were regionally localized to human prometaphase chromosomes by in situ hybridization. The localization of these cosmids suggests that a number of finger protein genes occur in linked clusters. Their assignment to chromosomes 3p, 11p, 19p, 19qter, 20p, and 21q makes them valuable as markers or "candidate" genes for diseases associated with these chromosome regions

U2 - https://doi.org/10.1016/0888-7543(92)90372-Y

DO - https://doi.org/10.1016/0888-7543(92)90372-Y

M3 - Article

C2 - 1740334

SN - 0888-7543

VL - 12

SP - 254

EP - 263

JO - Genomics

JF - Genomics

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