TY - JOUR
T1 - High tolerance for oral galactose in classical galactosaemia: dietary implications
AU - Bosch, A.M.
AU - Bakker, H.D.
AU - Wenniger-Prick, L.J.J.M.
AU - Wanders, R.J.A.
AU - Wijburg, F.A.
N1 - gem/08 reprint. Copyright: BMJ Publishing Group
PY - 2004
Y1 - 2004
N2 - AIM: To study the relevance of restricting the exogenous intake of small amounts of galactose, such as from fruit and vegetables, in patients with classical galactosaemia. METHODS: For a period of six weeks, increasing doses of oral galactose to a maximum of 600 mg per day, were added to a very strict galactose restricted diet in three adolescent patients homozygous for the Q188R mutation. During the study, physical examination, including an extended ophthalmic examination, and laboratory studies were performed on a weekly basis. RESULTS: No significant change in any of the studied clinical or biochemical parameters was observed. CONCLUSIONS: These findings provide further evidence that attempts to exclude trace amounts of galactose from the diet are not justified. Once the diet is made more liberal, a long term follow up study will be necessary
AB - AIM: To study the relevance of restricting the exogenous intake of small amounts of galactose, such as from fruit and vegetables, in patients with classical galactosaemia. METHODS: For a period of six weeks, increasing doses of oral galactose to a maximum of 600 mg per day, were added to a very strict galactose restricted diet in three adolescent patients homozygous for the Q188R mutation. During the study, physical examination, including an extended ophthalmic examination, and laboratory studies were performed on a weekly basis. RESULTS: No significant change in any of the studied clinical or biochemical parameters was observed. CONCLUSIONS: These findings provide further evidence that attempts to exclude trace amounts of galactose from the diet are not justified. Once the diet is made more liberal, a long term follow up study will be necessary
KW - AMC wi-co
U2 - https://doi.org/10.1136/adc.2003.037671
DO - https://doi.org/10.1136/adc.2003.037671
M3 - Article
C2 - 15499058
SN - 0003-9888
VL - 89
SP - 1034
EP - 1036
JO - Archives of disease in childhood
JF - Archives of disease in childhood
IS - 11
ER -