High vaccine effectiveness persists for ten years after HPV16/18 vaccination among young Dutch women

Joske Hoes; Audrey J. King; Johannes Berkhof; Hester E. de Melker

doi:https://doi.org/10.1016/j.vaccine.2022.11.057

High vaccine effectiveness persists for ten years after HPV16/18 vaccination among young Dutch women

Joske Hoes, Audrey J. King, Johannes Berkhof, Hester E. de Melker

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

The current study describes the long-term effectiveness of three-dose HPV16/18 vaccination among Dutch women who were eligible for vaccination during a catch-up campaign and were followed in an observational cohort study. Ten years post vaccination, vaccine effectiveness (VE) was estimated using generalized estimating equation models. VE against persistent infections with vaccine type infections (HPV16/18) was high at 95.8%. For cross protective type persistent infections (HPV31/33/45) this was 64.6%. There were no indications of waning of protection over time. This indicates solid long-term protection is provided by the vaccine and is promising with regard to the future clinical impact.

Original language	English
Pages (from-to)	285-289
Number of pages	5
Journal	Vaccine
Volume	41
Issue number	2
Early online date	2022
DOIs	https://doi.org/10.1016/j.vaccine.2022.11.057
Publication status	Published - 9 Jan 2023

Keywords

Human papillomavirus
Observational study
Vaccine effectiveness

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https://doi.org/10.1016/j.vaccine.2022.11.057

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title = "High vaccine effectiveness persists for ten years after HPV16/18 vaccination among young Dutch women",

abstract = "The current study describes the long-term effectiveness of three-dose HPV16/18 vaccination among Dutch women who were eligible for vaccination during a catch-up campaign and were followed in an observational cohort study. Ten years post vaccination, vaccine effectiveness (VE) was estimated using generalized estimating equation models. VE against persistent infections with vaccine type infections (HPV16/18) was high at 95.8%. For cross protective type persistent infections (HPV31/33/45) this was 64.6%. There were no indications of waning of protection over time. This indicates solid long-term protection is provided by the vaccine and is promising with regard to the future clinical impact.",

keywords = "Human papillomavirus, Observational study, Vaccine effectiveness",

author = "Joske Hoes and King, {Audrey J.} and Johannes Berkhof and {de Melker}, {Hester E.}",

note = "Funding Information: This work was supported by the Dutch Ministry of Public Health, Welfare and Sports. Funding Information: We would like to gratefully acknowledge the following people for their valuable contributions to either study design, data collection, laboratory analyses, or statistical analyses: Elske van Logchem, Naomi van Marm, Tim Severs, Najima Lamkaraf, Tsira Dzebisasjvili, Suzan Leussink, Robine Donken, and Madelief Mollers. This work was supported by the Dutch Ministry of Public Health, Welfare and Sports. Publisher Copyright: {\textcopyright} 2022",

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AU - de Melker, Hester E.

N1 - Funding Information: This work was supported by the Dutch Ministry of Public Health, Welfare and Sports. Funding Information: We would like to gratefully acknowledge the following people for their valuable contributions to either study design, data collection, laboratory analyses, or statistical analyses: Elske van Logchem, Naomi van Marm, Tim Severs, Najima Lamkaraf, Tsira Dzebisasjvili, Suzan Leussink, Robine Donken, and Madelief Mollers. This work was supported by the Dutch Ministry of Public Health, Welfare and Sports. Publisher Copyright: © 2022

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AB - The current study describes the long-term effectiveness of three-dose HPV16/18 vaccination among Dutch women who were eligible for vaccination during a catch-up campaign and were followed in an observational cohort study. Ten years post vaccination, vaccine effectiveness (VE) was estimated using generalized estimating equation models. VE against persistent infections with vaccine type infections (HPV16/18) was high at 95.8%. For cross protective type persistent infections (HPV31/33/45) this was 64.6%. There were no indications of waning of protection over time. This indicates solid long-term protection is provided by the vaccine and is promising with regard to the future clinical impact.

KW - Human papillomavirus

KW - Observational study

KW - Vaccine effectiveness

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High vaccine effectiveness persists for ten years after HPV16/18 vaccination among young Dutch women

Abstract

Keywords

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