Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia: Cause or consequence of preeclampsia

J. R. Prins; M. L. P. van der Hoorn; R. Keijser; C. Ris-Stalpers; E. van Beelen; G. B. Afink; F. H. J. Claas; J. A. M. van der Post; S. A. Scherjon

doi:https://doi.org/10.1016/j.humimm.2015.10.004

Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia: Cause or consequence of preeclampsia

J. R. Prins, M. L. P. van der Hoorn, R. Keijser, C. Ris-Stalpers, E. van Beelen, G. B. Afink, F. H. J. Claas, J. A. M. van der Post, S. A. Scherjon

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-27) and IL-35. EBI3 has been reported to associate with HLA-G. In this small pilot study we find higher decidual EBI3 (p <0.05) and HLA-G (p <0.01) mRNA expression in preeclampsia (n=7) compared to normotensive (n=8) pregnancies. Whether the higher EBI3 and HLA-G mRNA expression is a consequence or cause of preeclampsia remains to be answered. Further research to determine the effects on IL-27 and IL-35 is needed

Original language	English
Pages (from-to)	68-70
Journal	Human immunology
Volume	77
Issue number	1
DOIs	https://doi.org/10.1016/j.humimm.2015.10.004
Publication status	Published - 2016

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https://doi.org/10.1016/j.humimm.2015.10.004

Cite this

@article{6825b2d3dfc944279a97638d59be998c,

title = "Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia: Cause or consequence of preeclampsia",

abstract = "The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-27) and IL-35. EBI3 has been reported to associate with HLA-G. In this small pilot study we find higher decidual EBI3 (p <0.05) and HLA-G (p <0.01) mRNA expression in preeclampsia (n=7) compared to normotensive (n=8) pregnancies. Whether the higher EBI3 and HLA-G mRNA expression is a consequence or cause of preeclampsia remains to be answered. Further research to determine the effects on IL-27 and IL-35 is needed",

author = "Prins, {J. R.} and {van der Hoorn}, {M. L. P.} and R. Keijser and C. Ris-Stalpers and {van Beelen}, E. and Afink, {G. B.} and Claas, {F. H. J.} and {van der Post}, {J. A. M.} and Scherjon, {S. A.}",

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T1 - Higher decidual EBI3 and HLA-G mRNA expression in preeclampsia: Cause or consequence of preeclampsia

AU - Prins, J. R.

AU - van der Hoorn, M. L. P.

AU - Keijser, R.

AU - Ris-Stalpers, C.

AU - van Beelen, E.

AU - Afink, G. B.

AU - Claas, F. H. J.

AU - van der Post, J. A. M.

AU - Scherjon, S. A.

PY - 2016

Y1 - 2016

N2 - The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-27) and IL-35. EBI3 has been reported to associate with HLA-G. In this small pilot study we find higher decidual EBI3 (p <0.05) and HLA-G (p <0.01) mRNA expression in preeclampsia (n=7) compared to normotensive (n=8) pregnancies. Whether the higher EBI3 and HLA-G mRNA expression is a consequence or cause of preeclampsia remains to be answered. Further research to determine the effects on IL-27 and IL-35 is needed

AB - The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-27) and IL-35. EBI3 has been reported to associate with HLA-G. In this small pilot study we find higher decidual EBI3 (p <0.05) and HLA-G (p <0.01) mRNA expression in preeclampsia (n=7) compared to normotensive (n=8) pregnancies. Whether the higher EBI3 and HLA-G mRNA expression is a consequence or cause of preeclampsia remains to be answered. Further research to determine the effects on IL-27 and IL-35 is needed

U2 - https://doi.org/10.1016/j.humimm.2015.10.004

DO - https://doi.org/10.1016/j.humimm.2015.10.004

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