TY - JOUR
T1 - Hippocampal volume change following ECT is mediated by rs699947 in the promotor region of VEGF
AU - van den Bossche, Maarten J. A.
AU - Emsell, Louise
AU - Dols, Annemiek
AU - Vansteelandt, Kristof
AU - de Winter, François-Laurent
AU - van den Stock, Jan
AU - Sienaert, Pascal
AU - Stek, Max L.
AU - Bouckaert, Filip
AU - Vandenbulcke, Mathieu
PY - 2019
Y1 - 2019
N2 - Several studies have shown that electroconvulsive therapy (ECT) results in increased hippocampal volume. It is likely that a multitude of mechanisms including neurogenesis, gliogenesis, synaptogenesis, angiogenesis, and vasculogenesis contribute to this volume increase. Neurotrophins, like vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) seem to play a crucial mediating role in several of these mechanisms. We hypothesized that two regulatory SNPs in the VEGF and BDNF gene influence the changes in hippocampal volume following ECT. We combined genotyping and brain MRI assessment in a sample of older adults suffering from major depressive disorder to test this hypothesis. Our results show an effect of rs699947 (in the promotor region of VEGF) on hippocampal volume changes following ECT. However, we did not find a clear effect of rs6265 (in BDNF). To the best of our knowledge, this is the first study investigating possible genetic mechanisms involved in hippocampal volume change during ECT treatment.
AB - Several studies have shown that electroconvulsive therapy (ECT) results in increased hippocampal volume. It is likely that a multitude of mechanisms including neurogenesis, gliogenesis, synaptogenesis, angiogenesis, and vasculogenesis contribute to this volume increase. Neurotrophins, like vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) seem to play a crucial mediating role in several of these mechanisms. We hypothesized that two regulatory SNPs in the VEGF and BDNF gene influence the changes in hippocampal volume following ECT. We combined genotyping and brain MRI assessment in a sample of older adults suffering from major depressive disorder to test this hypothesis. Our results show an effect of rs699947 (in the promotor region of VEGF) on hippocampal volume changes following ECT. However, we did not find a clear effect of rs6265 (in BDNF). To the best of our knowledge, this is the first study investigating possible genetic mechanisms involved in hippocampal volume change during ECT treatment.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071035363&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31431610
U2 - https://doi.org/10.1038/s41398-019-0530-6
DO - https://doi.org/10.1038/s41398-019-0530-6
M3 - Article
C2 - 31431610
SN - 2158-3188
VL - 9
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 191
ER -