Abstract
We have over the years studied several sequence or structural elements within the HIV-1 RNA genome. Molecular mechanisms have been proposed for the role of these RNA motifs in virus replication. We have developed HIV-1 evolution as a powerful research method to study different aspects of the viral replication cycle. In this manuscript, I will illustrate the unique capacity of this method to reveal new mechanistic information about viral replication strategies. Examples of HIV-1 RNA evolution that were presented at the 2009 Cantoblanco meeting in Madrid will be discussed, ranging from the control of HIV-1 splicing by RNA structure to the role of cellular tRNA molecules as adaptors in an unusual HIV-1 recombination event, and from regulation of polyadenylation by RNA structure to viral escape from therapeutic pressure imposed by antiviral RNA interference
Original language | English |
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Pages (from-to) | 225-229 |
Journal | RNA biology |
Volume | 8 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2011 |