TY - JOUR
T1 - HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021
T2 - be alert to emtricitabine/tenofovir-resistant strain transmission
AU - Koole, Jeffrey C. D.
AU - de la Court, Feline
AU - Welkers, Matthijs R. A.
AU - Yap, Kenneth
AU - Stalenhoef, Janneke E.
AU - Jurriaans, Suzanne
AU - de Vries, Henry J. C.
AU - de Coul, Eline L. M. Op
AU - Prins, Maria
AU - Hoornenborg, Elske
N1 - Publisher Copyright: © 2022 European Centre for Disease Prevention and Control (ECDC). All rights reserved.
PY - 2022/4/7
Y1 - 2022/4/7
N2 - In August 2021, a man who has sex with men was diagnosed with HIV-1 infection despite using eventdriven pre-exposure prophylaxis for over 2 years with self-reported excellent adherence. Sequencing identified resistance-associated mutations (RAM) M184V and K65R, conferring resistance to emtricitabine and tenofovir, and RAM V108I and E138A. Background RAM prevalence was two of 164 (1.2%) new HIV diagnoses in Amsterdam (2017-19). We reiterate the need for frequent HIV testing among PrEP users and additional testing in case of symptoms.
AB - In August 2021, a man who has sex with men was diagnosed with HIV-1 infection despite using eventdriven pre-exposure prophylaxis for over 2 years with self-reported excellent adherence. Sequencing identified resistance-associated mutations (RAM) M184V and K65R, conferring resistance to emtricitabine and tenofovir, and RAM V108I and E138A. Background RAM prevalence was two of 164 (1.2%) new HIV diagnoses in Amsterdam (2017-19). We reiterate the need for frequent HIV testing among PrEP users and additional testing in case of symptoms.
UR - http://www.scopus.com/inward/record.url?scp=85129006385&partnerID=8YFLogxK
U2 - https://doi.org/10.2807/1560-7917.ES.2022.27.14.2100284
DO - https://doi.org/10.2807/1560-7917.ES.2022.27.14.2100284
M3 - Article
C2 - 35393931
SN - 1025-496X
VL - 27
JO - Euro surveillance
JF - Euro surveillance
IS - 14
ER -