TY - JOUR
T1 - HIV persistence
T2 - silence or resistance?
AU - Pasternak, Alexander O.
AU - Berkhout, Ben
N1 - Funding Information: This work was supported by the grant no. 09120011910035 from the Dutch Medical Research Council (ZonMw). Publisher Copyright: © 2023 The Author(s)
PY - 2023/4/1
Y1 - 2023/4/1
N2 - Despite decades of suppressive antiretroviral therapy, human immunodeficiency virus (HIV) reservoirs in infected individuals persist and fuel viral rebound once therapy is interrupted. The persistence of viral reservoirs is the main obstacle to achieving HIV eradication or a long-term remission. The last decade has seen a profound change in our understanding of the mechanisms behind HIV persistence, which appears to be much more complex than originally assumed. In addition to the persistence of transcriptionally silent proviruses in a stable latent reservoir that is invisible to the immune system, HIV is increasingly recognized to persist by resistance to the immune clearance, which appears to play a surprisingly prominent role in shaping the reservoir. In this review, we discuss some emerging insights into the mechanisms of HIV persistence, as well as their implications for the development of strategies towards an HIV cure.
AB - Despite decades of suppressive antiretroviral therapy, human immunodeficiency virus (HIV) reservoirs in infected individuals persist and fuel viral rebound once therapy is interrupted. The persistence of viral reservoirs is the main obstacle to achieving HIV eradication or a long-term remission. The last decade has seen a profound change in our understanding of the mechanisms behind HIV persistence, which appears to be much more complex than originally assumed. In addition to the persistence of transcriptionally silent proviruses in a stable latent reservoir that is invisible to the immune system, HIV is increasingly recognized to persist by resistance to the immune clearance, which appears to play a surprisingly prominent role in shaping the reservoir. In this review, we discuss some emerging insights into the mechanisms of HIV persistence, as well as their implications for the development of strategies towards an HIV cure.
UR - http://www.scopus.com/inward/record.url?scp=85148325617&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.coviro.2023.101301
DO - https://doi.org/10.1016/j.coviro.2023.101301
M3 - Review article
C2 - 36805974
SN - 1879-6257
VL - 59
JO - Current opinion in virology
JF - Current opinion in virology
M1 - 101301
ER -