@article{58960c9c09bb48ae90db352a8b96b717,
title = "Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1",
abstract = "Raina and Vader demonstrate a general role for budding yeast AAA+ ATPase Pch2, in collaboration with the HORMA protein Hop1, in meiotic prophase checkpoint function. Pch2 can activate or silence checkpoint function. Synaptonemal complex polymerization dictates switch-like behavior of Pch2 function in the meiotic checkpoint.",
keywords = "AAA+ ATPase, DNA repair, HORMA domain, checkpoint, meiosis, recombination, synapsis",
author = "Raina, {Vivek B.} and Gerben Vader",
note = "Funding Information: We thank the Vader and Bird laboratories for ideas and discussions. We thank Divya Singh for helpful discussions on the experimental design. We thank Andrea Musacchio for ongoing support throughout this project. We thank Ad{\`e}le Marston, John Weir, Andrea Musacchio, Marcel van Vugt, Divya Singh, Vaishnavi Nivsarkar, Richard Cardoso da Silva, and Arnaud Rondelet for comments on the manuscript. We acknowledge Amy MacQueen for sharing reagents. This work was financially supported by the European Research Council (ERC starting grant URDNA, agreement no. 638197 , to G.V.) and the Max Planck Society . The ORCIDs for this article are 0000-0003-0507-9208 (V.B.R.) and 0000-0001-5729-0991 (G.V.). Funding Information: We thank the Vader and Bird laboratories for ideas and discussions. We thank Divya Singh for helpful discussions on the experimental design. We thank Andrea Musacchio for ongoing support throughout this project. We thank Ad?le Marston, John Weir, Andrea Musacchio, Marcel van Vugt, Divya Singh, Vaishnavi Nivsarkar, Richard Cardoso da Silva, and Arnaud Rondelet for comments on the manuscript. We acknowledge Amy MacQueen for sharing reagents. This work was financially supported by the European Research Council (ERC starting grant URDNA, agreement no. 638197, to G.V.) and the Max Planck Society. The ORCIDs for this article are 0000-0003-0507-9208 (V.B.R.) and 0000-0001-5729-0991 (G.V.). V.B.R. conceptualized the idea and model of this study and performed experiments and analysis, with the exception of Southern blot analysis, which was performed by G.V. V.B.R. and G.V. conceived and designed experiments and wrote the manuscript. G.V. supervised the study and acquired funds. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s) Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = nov,
day = "16",
doi = "https://doi.org/10.1016/j.cub.2020.08.064",
language = "English",
volume = "30",
pages = "4413--4424.e5",
journal = "Current biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "22",
}