Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1

Vivek B. Raina, Gerben Vader

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20 Citations (Scopus)


Raina and Vader demonstrate a general role for budding yeast AAA+ ATPase Pch2, in collaboration with the HORMA protein Hop1, in meiotic prophase checkpoint function. Pch2 can activate or silence checkpoint function. Synaptonemal complex polymerization dictates switch-like behavior of Pch2 function in the meiotic checkpoint.

Original languageEnglish
Pages (from-to)4413-4424.e5
JournalCurrent biology
Issue number22
Publication statusPublished - 16 Nov 2020


  • AAA+ ATPase
  • DNA repair
  • HORMA domain
  • checkpoint
  • meiosis
  • recombination
  • synapsis

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