Hormones in the critically ill patient: To intervene or not to intervene?

J. Ligtenberg, A. Girbes, J. Beentjes, J. Tulleken, T. Werf, J. Zijlstra

Research output: Contribution to journalReview articleAcademicpeer-review

33 Citations (Scopus)


Critically ill patients show a variety of hormonal changes that appear to differ considerably in acute and prolonged critical illness. Whether these endocrine alterations serve as physiological adaptation or contribute to further deterioration remains an intriguing question. We review the recent literature and discuss whether measuring circulating hormone concentrations, performing stimulation tests, and intervening with hormone substitution could contribute to the recovery of critically ill patients.

Original languageEnglish
Pages (from-to)1567-1577
Number of pages11
JournalIntensive care medicine
Issue number10
Publication statusPublished - 13 Nov 2001


  • Cortisol
  • Critical illness
  • Growth hormone
  • Insulin resistance
  • Intensive care
  • Norepinephrine
  • Prolactin
  • Relative adrenal insufficiency syndrome
  • Synacthen
  • Thyroid hormones

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