TY - JOUR
T1 - Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis
AU - Brouwer, Matthijs C.
AU - de Gans, Jan
AU - Heckenberg, Sebastiaan G. B.
AU - Zwinderman, Aeilko H.
AU - van der Poll, Tom
AU - van de Beek, Diederik
PY - 2009
Y1 - 2009
N2 - Streptococcus pneumoniae and Neisseria meningitidis can cause sepsis and meningitis. Several risk factors for pneumococcal and meningococcal disease have been identified, but the cause of basic differences in susceptibility between individuals and populations is unknown. Single-nucleotide polymorphisms are thought to explain interindividual differences in susceptibility. New technologies provide the opportunity to study the genetic basis of susceptibility to these diseases. In recent years, several studies have been published on these polymorphisms in pneumococcal and meningococcal disease, many with apparently conflicting results. Herein we provide a systematic overview of all polymorphisms studied for a relation with susceptibility to pneumococcal and meningococcal disease. We also propose an initiative to pool genetic data on pneumococcal and meningococcal meningitis in one biobank
AB - Streptococcus pneumoniae and Neisseria meningitidis can cause sepsis and meningitis. Several risk factors for pneumococcal and meningococcal disease have been identified, but the cause of basic differences in susceptibility between individuals and populations is unknown. Single-nucleotide polymorphisms are thought to explain interindividual differences in susceptibility. New technologies provide the opportunity to study the genetic basis of susceptibility to these diseases. In recent years, several studies have been published on these polymorphisms in pneumococcal and meningococcal disease, many with apparently conflicting results. Herein we provide a systematic overview of all polymorphisms studied for a relation with susceptibility to pneumococcal and meningococcal disease. We also propose an initiative to pool genetic data on pneumococcal and meningococcal meningitis in one biobank
U2 - https://doi.org/10.1016/S1473-3099(08)70261-5
DO - https://doi.org/10.1016/S1473-3099(08)70261-5
M3 - Review article
C2 - 19036641
SN - 1473-3099
VL - 9
SP - 31
EP - 44
JO - Lancet infectious diseases
JF - Lancet infectious diseases
IS - 1
ER -