Abstract
The integrin leukocyte function-associated antigen 1 (LFA-1) is pivotal for cell adhesion and signalling within the immune system. Here, Minke Binnerts and Yvette van Kooyk discuss evidence from mutational and crystallographic studies showing that binding of LFA-1 to its ligands intercellular adhesion molecule 1 (ICAM-1), -2 and -3 might be structurally distinct.
| Original language | English |
|---|---|
| Pages (from-to) | 240-5 |
| Number of pages | 6 |
| Journal | Immunology today |
| Volume | 20 |
| Issue number | 5 |
| Publication status | Published - May 1999 |
Keywords
- Animals
- Binding Sites
- Cell Adhesion Molecules/metabolism
- Humans
- Ligands
- Lymphocyte Function-Associated Antigen-1/chemistry
- Models, Molecular
- Protein Conformation