How LFA-1 binds to different ligands

M E Binnerts, Y van Kooyk

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)


The integrin leukocyte function-associated antigen 1 (LFA-1) is pivotal for cell adhesion and signalling within the immune system. Here, Minke Binnerts and Yvette van Kooyk discuss evidence from mutational and crystallographic studies showing that binding of LFA-1 to its ligands intercellular adhesion molecule 1 (ICAM-1), -2 and -3 might be structurally distinct.

Original languageEnglish
Pages (from-to)240-5
Number of pages6
JournalImmunology today
Issue number5
Publication statusPublished - May 1999


  • Animals
  • Binding Sites
  • Cell Adhesion Molecules/metabolism
  • Humans
  • Ligands
  • Lymphocyte Function-Associated Antigen-1/chemistry
  • Models, Molecular
  • Protein Conformation

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