How the COVID-19 pandemic highlights the necessity of animal research

L. Genzel; R. Adan; A. Berns; J.J.J.P. van den Beucken; A. Blokland; E.H.W.G.M. Boddeke; W.M. Bogers; R. Bontrop; R Bulthuis; T. Bousema; H. Clevers; T.C.J.J. Coenen; A.-M. van Dam; P.M.T. Deen; K.W. van Dijk; B.J.L. Eggen; Y. Elgersma; I. Erdogan; B. Englitz; J.M. Fentener van Vlissingen; S. la Fleur; R. Fouchier; C.P. Fitzsimons; W. Frieling; B. Haagmans; B.A. Heesters; M.J.A.G Henckens; S. Herfst; E. Hol; D. van den Hove; M.I. de Jonge; J. Jonkers; L.A.B. Joosten; A. Kalsbeek; M. Kamermans; H.H. Kampinga; M.J. Kas; J. Keijer; S. Kersten; A.J. Kiliaan; T.W.A. Kooij; S. Kooijman; W.J.H. Koopman; A. Korosi; H.J. Krugers; T. Kuiken; S.A. Kushner; J.A.M. Langermans; H.M.B. Lesscher; P.J. Lucassen; E. Lutgens; M.G. Netea; L.P.J.J. Noldus; J.W.M. van der Meer; F.J. Meye; J.D. Mul; K. van Oers; J.D.A. Olivier; R.J. Pasterkamp; I.H.C.H.M. Philippens; J. Prickaerts; B.J.A. Pollux; P.C.N. Rensen; J. van Rheenen; R.P. van Rij; L. Ritsma; B.H.G. Rockx; B. Roozendaal; E.M. van Schothorst; K. Stittelaar; N. Stockhofe; D.F. Swaab; R.L. de Swart; L.J.M.J. Vanderschuren; T.J. de Vries; F. de Vrij; R. van Wezel; C.J. Wierenga; M. Wiesmann; I. Willuhn; C.I. de Zeeuw; J.R. Homberg; Bart J A Pullox

doi:https://doi.org/10.1016/j.cub.2020.08.030

How the COVID-19 pandemic highlights the necessity of animal research

L. Genzel, R. Adan, A. Berns, J.J.J.P. van den Beucken, A. Blokland, E.H.W.G.M. Boddeke, W.M. Bogers, R. Bontrop, R Bulthuis, T. Bousema, H. Clevers, T.C.J.J. Coenen, A.-M. van Dam, P.M.T. Deen, K.W. van Dijk, B.J.L. Eggen, Y. Elgersma, I. Erdogan, B. Englitz, J.M. Fentener van VlissingenS. la Fleur, R. Fouchier, C.P. Fitzsimons, W. Frieling, B. Haagmans, B.A. Heesters, M.J.A.G Henckens, S. Herfst, E. Hol, D. van den Hove, M.I. de Jonge, J. Jonkers, L.A.B. Joosten, A. Kalsbeek, M. Kamermans, H.H. Kampinga, M.J. Kas, J. Keijer, S. Kersten, A.J. Kiliaan, T.W.A. Kooij, S. Kooijman, W.J.H. Koopman, A. Korosi, H.J. Krugers, T. Kuiken, S.A. Kushner, J.A.M. Langermans, H.M.B. Lesscher, P.J. Lucassen, E. Lutgens, M.G. Netea, L.P.J.J. Noldus, J.W.M. van der Meer, F.J. Meye, J.D. Mul, K. van Oers, J.D.A. Olivier, R.J. Pasterkamp, I.H.C.H.M. Philippens, J. Prickaerts, B.J.A. Pollux, P.C.N. Rensen, J. van Rheenen, R.P. van Rij, L. Ritsma, B.H.G. Rockx, B. Roozendaal, E.M. van Schothorst, K. Stittelaar, N. Stockhofe, D.F. Swaab, R.L. de Swart, L.J.M.J. Vanderschuren, T.J. de Vries, F. de Vrij, R. van Wezel, C.J. Wierenga, M. Wiesmann, I. Willuhn, C.I. de Zeeuw, J.R. Homberg, Bart J A Pullox

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium on the use of animals in science is not yet possible, there has been a push by the non-scientific community and politicians for a rapid transition to animal-free innovations. Although there are benefits for both animal welfare and researchers, advances on alternative methods have not progressed enough to be able to replace animal research in the foreseeable future. This trend has led first and foremost to a substantial increase in the administrative burden and hurdles required to make timely advances in research and treatments for human and animal diseases. The current COVID-19 pandemic clearly highlights how much we actually rely on animal research. COVID-19 affects several organs and systems, and the various animal-free alternatives currently available do not come close to this complexity. In this Essay, we therefore argue that the use of animals is essential for the advancement of human and veterinary health.

Original language	English
Pages (from-to)	R1014-R1018
Journal	Current biology
Volume	30
Issue number	18
DOIs	https://doi.org/10.1016/j.cub.2020.08.030
Publication status	Published - 21 Sept 2020

Keywords

Animal Experimentation
Animals
Betacoronavirus
Biomedical Research
COVID-19
Coronavirus Infections
Disease Models, Animal
Humans
Pandemics
Pneumonia, Viral
SARS-CoV-2

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Genzel, L., Adan, R., Berns, A., van den Beucken, J. J. J. P., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., van Dam, A.-M., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., ... Pullox, B. J. A. (2020). How the COVID-19 pandemic highlights the necessity of animal research. Current biology, 30(18), R1014-R1018. https://doi.org/10.1016/j.cub.2020.08.030

@article{467eb89cd5d74aa3b10699ed6932c8fe,

title = "How the COVID-19 pandemic highlights the necessity of animal research",

abstract = "Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium on the use of animals in science is not yet possible, there has been a push by the non-scientific community and politicians for a rapid transition to animal-free innovations. Although there are benefits for both animal welfare and researchers, advances on alternative methods have not progressed enough to be able to replace animal research in the foreseeable future. This trend has led first and foremost to a substantial increase in the administrative burden and hurdles required to make timely advances in research and treatments for human and animal diseases. The current COVID-19 pandemic clearly highlights how much we actually rely on animal research. COVID-19 affects several organs and systems, and the various animal-free alternatives currently available do not come close to this complexity. In this Essay, we therefore argue that the use of animals is essential for the advancement of human and veterinary health.",

keywords = "Animal Experimentation, Animals, Betacoronavirus, Biomedical Research, COVID-19, Coronavirus Infections, Disease Models, Animal, Humans, Pandemics, Pneumonia, Viral, SARS-CoV-2",

author = "L. Genzel and R. Adan and A. Berns and {van den Beucken}, J.J.J.P. and A. Blokland and E.H.W.G.M. Boddeke and W.M. Bogers and R. Bontrop and R Bulthuis and T. Bousema and H. Clevers and T.C.J.J. Coenen and {van Dam}, A.-M. and P.M.T. Deen and {van Dijk}, K.W. and B.J.L. Eggen and Y. Elgersma and I. Erdogan and B. Englitz and {Fentener van Vlissingen}, J.M. and {la Fleur}, S. and R. Fouchier and C.P. Fitzsimons and W. Frieling and B. Haagmans and B.A. Heesters and M.J.A.G Henckens and S. Herfst and E. Hol and {van den Hove}, D. and {de Jonge}, M.I. and J. Jonkers and L.A.B. Joosten and A. Kalsbeek and M. Kamermans and H.H. Kampinga and M.J. Kas and J. Keijer and S. Kersten and A.J. Kiliaan and T.W.A. Kooij and S. Kooijman and W.J.H. Koopman and A. Korosi and H.J. Krugers and T. Kuiken and S.A. Kushner and J.A.M. Langermans and H.M.B. Lesscher and P.J. Lucassen and E. Lutgens and M.G. Netea and L.P.J.J. Noldus and {van der Meer}, J.W.M. and F.J. Meye and J.D. Mul and {van Oers}, K. and J.D.A. Olivier and R.J. Pasterkamp and I.H.C.H.M. Philippens and J. Prickaerts and B.J.A. Pollux and P.C.N. Rensen and {van Rheenen}, J. and {van Rij}, R.P. and L. Ritsma and B.H.G. Rockx and B. Roozendaal and {van Schothorst}, E.M. and K. Stittelaar and N. Stockhofe and D.F. Swaab and {de Swart}, R.L. and L.J.M.J. Vanderschuren and {de Vries}, T.J. and {de Vrij}, F. and {van Wezel}, R. and C.J. Wierenga and M. Wiesmann and I. Willuhn and {de Zeeuw}, C.I. and J.R. Homberg and Pullox, {Bart J A}",

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language = "English",

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pages = "R1014--R1018",

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Genzel, L, Adan, R, Berns, A, van den Beucken, JJJP, Blokland, A, Boddeke, EHWGM, Bogers, WM, Bontrop, R, Bulthuis, R, Bousema, T, Clevers, H, Coenen, TCJJ, van Dam, A-M, Deen, PMT, van Dijk, KW, Eggen, BJL, Elgersma, Y, Erdogan, I, Englitz, B, Fentener van Vlissingen, JM, la Fleur, S, Fouchier, R, Fitzsimons, CP, Frieling, W, Haagmans, B, Heesters, BA, Henckens, MJAG, Herfst, S, Hol, E, van den Hove, D, de Jonge, MI, Jonkers, J, Joosten, LAB, Kalsbeek, A , Kamermans, M, Kampinga, HH, Kas, MJ, Keijer, J, Kersten, S, Kiliaan, AJ, Kooij, TWA, Kooijman, S, Koopman, WJH, Korosi, A, Krugers, HJ, Kuiken, T, Kushner, SA, Langermans, JAM, Lesscher, HMB, Lucassen, PJ, Lutgens, E, Netea, MG, Noldus, LPJJ, van der Meer, JWM, Meye, FJ, Mul, JD, van Oers, K, Olivier, JDA, Pasterkamp, RJ, Philippens, IHCHM, Prickaerts, J, Pollux, BJA, Rensen, PCN, van Rheenen, J, van Rij, RP, Ritsma, L, Rockx, BHG, Roozendaal, B, van Schothorst, EM, Stittelaar, K, Stockhofe, N, Swaab, DF, de Swart, RL, Vanderschuren, LJMJ, de Vries, TJ, de Vrij, F, van Wezel, R, Wierenga, CJ, Wiesmann, M, Willuhn, I, de Zeeuw, CI, Homberg, JR & Pullox, BJA 2020, 'How the COVID-19 pandemic highlights the necessity of animal research', Current biology, vol. 30, no. 18, pp. R1014-R1018. https://doi.org/10.1016/j.cub.2020.08.030

TY - JOUR

T1 - How the COVID-19 pandemic highlights the necessity of animal research

AU - Genzel, L.

AU - Adan, R.

AU - Berns, A.

AU - van den Beucken, J.J.J.P.

AU - Blokland, A.

AU - Boddeke, E.H.W.G.M.

AU - Bogers, W.M.

AU - Bontrop, R.

AU - Bulthuis, R

AU - Bousema, T.

AU - Clevers, H.

AU - Coenen, T.C.J.J.

AU - van Dam, A.-M.

AU - Deen, P.M.T.

AU - van Dijk, K.W.

AU - Eggen, B.J.L.

AU - Elgersma, Y.

AU - Erdogan, I.

AU - Englitz, B.

AU - Fentener van Vlissingen, J.M.

AU - la Fleur, S.

AU - Fouchier, R.

AU - Fitzsimons, C.P.

AU - Frieling, W.

AU - Haagmans, B.

AU - Heesters, B.A.

AU - Henckens, M.J.A.G

AU - Herfst, S.

AU - Hol, E.

AU - van den Hove, D.

AU - de Jonge, M.I.

AU - Jonkers, J.

AU - Joosten, L.A.B.

AU - Kalsbeek, A.

AU - Kamermans, M.

AU - Kampinga, H.H.

AU - Kas, M.J.

AU - Keijer, J.

AU - Kersten, S.

AU - Kiliaan, A.J.

AU - Kooij, T.W.A.

AU - Kooijman, S.

AU - Koopman, W.J.H.

AU - Korosi, A.

AU - Krugers, H.J.

AU - Kuiken, T.

AU - Kushner, S.A.

AU - Langermans, J.A.M.

AU - Lesscher, H.M.B.

AU - Lucassen, P.J.

AU - Lutgens, E.

AU - Netea, M.G.

AU - Noldus, L.P.J.J.

AU - van der Meer, J.W.M.

AU - Meye, F.J.

AU - Mul, J.D.

AU - van Oers, K.

AU - Olivier, J.D.A.

AU - Pasterkamp, R.J.

AU - Philippens, I.H.C.H.M.

AU - Prickaerts, J.

AU - Pollux, B.J.A.

AU - Rensen, P.C.N.

AU - van Rheenen, J.

AU - van Rij, R.P.

AU - Ritsma, L.

AU - Rockx, B.H.G.

AU - Roozendaal, B.

AU - van Schothorst, E.M.

AU - Stittelaar, K.

AU - Stockhofe, N.

AU - Swaab, D.F.

AU - de Swart, R.L.

AU - Vanderschuren, L.J.M.J.

AU - de Vries, T.J.

AU - de Vrij, F.

AU - van Wezel, R.

AU - Wierenga, C.J.

AU - Wiesmann, M.

AU - Willuhn, I.

AU - de Zeeuw, C.I.

AU - Homberg, J.R.

AU - Pullox, Bart J A

PY - 2020/9/21

Y1 - 2020/9/21

N2 - Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium on the use of animals in science is not yet possible, there has been a push by the non-scientific community and politicians for a rapid transition to animal-free innovations. Although there are benefits for both animal welfare and researchers, advances on alternative methods have not progressed enough to be able to replace animal research in the foreseeable future. This trend has led first and foremost to a substantial increase in the administrative burden and hurdles required to make timely advances in research and treatments for human and animal diseases. The current COVID-19 pandemic clearly highlights how much we actually rely on animal research. COVID-19 affects several organs and systems, and the various animal-free alternatives currently available do not come close to this complexity. In this Essay, we therefore argue that the use of animals is essential for the advancement of human and veterinary health.

AB - Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium on the use of animals in science is not yet possible, there has been a push by the non-scientific community and politicians for a rapid transition to animal-free innovations. Although there are benefits for both animal welfare and researchers, advances on alternative methods have not progressed enough to be able to replace animal research in the foreseeable future. This trend has led first and foremost to a substantial increase in the administrative burden and hurdles required to make timely advances in research and treatments for human and animal diseases. The current COVID-19 pandemic clearly highlights how much we actually rely on animal research. COVID-19 affects several organs and systems, and the various animal-free alternatives currently available do not come close to this complexity. In this Essay, we therefore argue that the use of animals is essential for the advancement of human and veterinary health.

KW - Animal Experimentation

KW - Animals

KW - Betacoronavirus

KW - Biomedical Research

KW - COVID-19

KW - Coronavirus Infections

KW - Disease Models, Animal

KW - Humans

KW - Pandemics

KW - Pneumonia, Viral

KW - SARS-CoV-2

UR - https://pure.uva.nl/ws/files/76013294/Correction_How_the_COVID_19_pandemic_highlights_the_necessity_of_animal_research.pdf

UR - http://www.scopus.com/inward/record.url?scp=85090938421&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.cub.2020.08.030

DO - https://doi.org/10.1016/j.cub.2020.08.030

M3 - Article

C2 - 32961149

SN - 0960-9822

VL - 30

SP - R1014-R1018

JO - Current biology

JF - Current biology

IS - 18

ER -

How the COVID-19 pandemic highlights the necessity of animal research

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Keywords

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