TY - JOUR
T1 - How to Integrate Personalized Medicine into Prevention? Recommendations from the Personalized Prevention of Chronic Diseases (PRECeDI) Consortium
T2 - Recommendations from the Personalized Prevention of Chronic Diseases (PRECeDI) Consortium
AU - Boccia, Stefania
AU - Pastorino, Roberta
AU - Ricciardi, Walter
AU - Ádány, R. za
AU - Barnhoorn, Floris
AU - Boffetta, Paolo
AU - Cornel, Martina C.
AU - de Vito, Corrado
AU - Gray, Muir
AU - Jani, Anant
AU - Lang, Michael
AU - Roldan, Jim
AU - Rosso, Annalisa
AU - Sánchez, José Manuel
AU - van Dujin, Cornelia M.
AU - van el, Carla G.
AU - Villari, Paolo
AU - Zawati, Ma'N. H.
N1 - Funding Information: Innovation Staff Exchange (RISE) under the grant agreement No. 645740 Publisher Copyright: © 2019 S. Karger AG, Basel. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2019
Y1 - 2019
N2 - Medical practitioners are increasingly adopting a personalized medicine (PM) approach involving individually tailored patient care. The Personalized Prevention of Chronic Diseases (PRECeDI) consortium project, funded within the Marie Skłodowska Curie Action (MSCA) Research and Innovation Staff Exchange (RISE) scheme, had fostered collaboration on PM research and training with special emphasis on the prevention of chronic diseases. From 2014 to 2018, the PRECeDI consortium trained 50 staff members on personalized prevention of chronic diseases through training and research. The acquisition of skills from researchers came from dedicated secondments from academic and nonacademic institutions aimed at training on several research topics related to personalized prevention of cancer and cardiovascular and neurodegenerative diseases. In detail, 5 research domains were addressed: (1) identification and validation of biomarkers for the primary prevention of cardiovascular diseases, secondary prevention of Alzheimer disease, and tertiary prevention of head and neck cancer; (2) economic evaluation of genomic applications; (3) ethical-legal and policy issues surrounding PM; (4) sociotechnical analysis of the pros and cons of informing healthy individuals on their genome; and (5) identification of organizational models for the provision of predictive genetic testing. Based on the results of the research carried out by the PRECeDI consortium, in November 2018, a set of recommendations for policy makers, scientists, and industry has been issued, with the main goal to foster the integration of PM approaches in the field of chronic disease prevention.
AB - Medical practitioners are increasingly adopting a personalized medicine (PM) approach involving individually tailored patient care. The Personalized Prevention of Chronic Diseases (PRECeDI) consortium project, funded within the Marie Skłodowska Curie Action (MSCA) Research and Innovation Staff Exchange (RISE) scheme, had fostered collaboration on PM research and training with special emphasis on the prevention of chronic diseases. From 2014 to 2018, the PRECeDI consortium trained 50 staff members on personalized prevention of chronic diseases through training and research. The acquisition of skills from researchers came from dedicated secondments from academic and nonacademic institutions aimed at training on several research topics related to personalized prevention of cancer and cardiovascular and neurodegenerative diseases. In detail, 5 research domains were addressed: (1) identification and validation of biomarkers for the primary prevention of cardiovascular diseases, secondary prevention of Alzheimer disease, and tertiary prevention of head and neck cancer; (2) economic evaluation of genomic applications; (3) ethical-legal and policy issues surrounding PM; (4) sociotechnical analysis of the pros and cons of informing healthy individuals on their genome; and (5) identification of organizational models for the provision of predictive genetic testing. Based on the results of the research carried out by the PRECeDI consortium, in November 2018, a set of recommendations for policy makers, scientists, and industry has been issued, with the main goal to foster the integration of PM approaches in the field of chronic disease prevention.
KW - Chronic diseases
KW - Personalized medicine
KW - Prevention
KW - Recommendations
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076695473&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31805565
UR - http://www.scopus.com/inward/record.url?scp=85076695473&partnerID=8YFLogxK
U2 - https://doi.org/10.1159/000504652
DO - https://doi.org/10.1159/000504652
M3 - Article
C2 - 31805565
SN - 1662-4246
VL - 22
SP - 208
EP - 214
JO - Public Health Genomics
JF - Public Health Genomics
IS - 5-6
ER -