TY - JOUR
T1 - HPV infections and flat penile lesions of the penis in men who have sex with men
AU - van Bilsen, Ward P. H.
AU - Kovaleva, Alexandra
AU - Bleeker, Maaike C. G.
AU - King, Audrey J.
AU - Bruisten, Sylvia M.
AU - Brokking, Wilma
AU - de Vries, Henry J. C.
AU - Meijer, Chris J. L. M.
AU - Schim van der Loeff, Maarten F.
N1 - Copyright © 2019. Published by Elsevier B.V.
PY - 2019/12
Y1 - 2019/12
N2 - Background: Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). Methods: In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous cohort. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. HPV viral load (VL) was determined using a quantitative type-specific (q)PCR targeting the L1-region. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL. Results: We included 116 MSM, of whom 59/116 (51%) MSM were HIV-positive and 54/116 (47%) had FPL. A penile HPV infection was present in 31/54 (57%) MSM with FPL and 34/62 (55%) MSM without FPL (p = 0.8). There was no difference between MSM with and without FPL regarding presence of penile HPV infection, HPV VL, HIV status or circumcision status (p > 0.05 for all). Conclusion: Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status.
AB - Background: Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). Methods: In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous cohort. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. HPV viral load (VL) was determined using a quantitative type-specific (q)PCR targeting the L1-region. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL. Results: We included 116 MSM, of whom 59/116 (51%) MSM were HIV-positive and 54/116 (47%) had FPL. A penile HPV infection was present in 31/54 (57%) MSM with FPL and 34/62 (55%) MSM without FPL (p = 0.8). There was no difference between MSM with and without FPL regarding presence of penile HPV infection, HPV VL, HIV status or circumcision status (p > 0.05 for all). Conclusion: Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status.
KW - Flat penile lesion
KW - HIV
KW - Human papillomavirus
KW - Men who have sex with men
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067693498&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31226447
U2 - https://doi.org/10.1016/j.pvr.2019.100173
DO - https://doi.org/10.1016/j.pvr.2019.100173
M3 - Article
C2 - 31226447
SN - 2405-8521
VL - 8
JO - Papillomavirus research
JF - Papillomavirus research
M1 - 100173
ER -