Human αB-crystallin (CRYA2) gene mapped to chromosome 11q12-q23

Ruud H. Brakenhoff, Ad H.M.Geurts van Kessel, Margot Oldenburg, Jules T. Wijnen, Hans Bloemendal, P. Meera Khan, John G.G. Schoenmakers

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The αB-crystallin gene (CRYA2) encodes the abundant lens protein αB-crystallin. A panel of human/ rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster αB-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q12-11q23.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalHuman genetics
Issue number2
Publication statusPublished - Jul 1990

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