Human dosimetry of the n-methyl-d-aspartate receptor ligand 11C-GMOM

Jasper Van Der Aart, Thalia F. Van Der Doef, Paul Horstman, Marc C. Huisman, Robert C. Schuit, Arthur Van Lingen, Albert D. Windhorst, Bart N.M. Van Berckel, Adriaan A. Lammertsma

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Abstract

The methylguaniDine derivative 11C-GMOM (11C-labeled N-(2-chloro-3-thiomethylphenyl)-N9-(3-methoxyphenyl)-N9-methylguaniDine) has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binDing in humans. The purpose of the present study was to estimate the 11C-GMOM raDiation dose in healthy humans. Methods: After 11C-GMOM injection, 3 female and 2 male subjects underwent 10 consecutive whole-body PET scans in approximately 77 min. Seven source organs were defined manually, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue-weighting factors were used to calculate the effective dose. Results: The mean absorbed raDiation doses in source organs ranged from 7.7 mGy-MBq21 in the brain to 12.7 mGy-MBq21 in the spleen. The effective dose (6SD) was 4.5 6 0.5 mSv-MBq21. Conclusion: The effective dose of 11C-GMOM is at the lower end of the range seen for other 11C-labeled ligands, allowing for serial PET scanning in a single subject.

Original languageEnglish
Pages (from-to)1330-1333
Number of pages4
JournalJournal of nuclear medicine
Volume58
Issue number8
DOIs
Publication statusPublished - 1 Aug 2017

Keywords

  • C
  • Dosimetry
  • NMDA
  • PET

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