Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence

A. B. van Kuilenburg; A. O. Muijsers; H. Demol; H. L. Dekker; J. J. van Beeumen

doi:https://doi.org/10.1016/0014-5793(88)80353-3

Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence

A. B. van Kuilenburg, A. O. Muijsers, H. Demol, H. L. Dekker, J. J. van Beeumen

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Abstract

Subunit VIII was purified from a preparation of the human heart cytochrome c oxidase and its complete amino acid sequence was determined. The sequence proved to be much more related to that of the bovine liver oxidase subunit VIII than to that found in bovine heart. Our finding of a 'liver-type' subunit VIII in the human heart enzyme suggests that either there are no isoforms of human subunit VIII or the human oxidase does not show the type of tissue specificity that has been reported for the oxidase in other mammals

Original language	English
Pages (from-to)	127-132
Journal	FEBS letters
Volume	240
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(88)80353-3
Publication status	Published - 1988

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https://doi.org/10.1016/0014-5793(88)80353-3

Cite this

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title = "Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence",

abstract = "Subunit VIII was purified from a preparation of the human heart cytochrome c oxidase and its complete amino acid sequence was determined. The sequence proved to be much more related to that of the bovine liver oxidase subunit VIII than to that found in bovine heart. Our finding of a 'liver-type' subunit VIII in the human heart enzyme suggests that either there are no isoforms of human subunit VIII or the human oxidase does not show the type of tissue specificity that has been reported for the oxidase in other mammals",

author = "{van Kuilenburg}, {A. B.} and Muijsers, {A. O.} and H. Demol and Dekker, {H. L.} and {van Beeumen}, {J. J.}",

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T1 - Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence

AU - van Kuilenburg, A. B.

AU - Muijsers, A. O.

AU - Demol, H.

AU - Dekker, H. L.

AU - van Beeumen, J. J.

PY - 1988

Y1 - 1988

N2 - Subunit VIII was purified from a preparation of the human heart cytochrome c oxidase and its complete amino acid sequence was determined. The sequence proved to be much more related to that of the bovine liver oxidase subunit VIII than to that found in bovine heart. Our finding of a 'liver-type' subunit VIII in the human heart enzyme suggests that either there are no isoforms of human subunit VIII or the human oxidase does not show the type of tissue specificity that has been reported for the oxidase in other mammals

AB - Subunit VIII was purified from a preparation of the human heart cytochrome c oxidase and its complete amino acid sequence was determined. The sequence proved to be much more related to that of the bovine liver oxidase subunit VIII than to that found in bovine heart. Our finding of a 'liver-type' subunit VIII in the human heart enzyme suggests that either there are no isoforms of human subunit VIII or the human oxidase does not show the type of tissue specificity that has been reported for the oxidase in other mammals

U2 - https://doi.org/10.1016/0014-5793(88)80353-3

DO - https://doi.org/10.1016/0014-5793(88)80353-3

M3 - Article

C2 - 2847943

SN - 0014-5793

VL - 240

SP - 127

EP - 132

JO - FEBS letters

JF - FEBS letters

IS - 1-2

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