Human lymph-node CD8(+) T cells display an altered phenotype during systemic autoimmunity

Tamara H. Ramwadhdoebe, Janine Hähnlein, Bo J. van Kuijk, Ivy Y. Choi, Leonard J. van Boven, Danielle M. Gerlag, Paul P. Tak, Lisa G. van Baarsen

Research output: Contribution to JournalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

Although many studies are focused on auto-reactive CD4(+) T cells, the precise role of CD8(+) T cells in autoimmunity is poorly understood. The objective of this study is to provide more insight into the phenotype and function CD8(+) T cells during the development of autoimmune disease by studying CD8(+) T cells in human lymph-node biopsies and peripheral blood obtained during the earliest phases of rheumatoid arthritis (RA). Here, we show that lymphoid pro-inflammatory CD8(+) T cells exhibit a less-responsive phenotype already during the earliest phases of autoimmunity compared with healthy individuals. We found an increase in CD8(+) memory T cells in lymphoid tissue during the earliest phases of autoimmunity, even before clinical onset of RA, accompanied by an increased frequency of non-circulating or recently activated (CD69(+)) CD8(+) T cells in lymphoid tissue and peripheral blood. Importantly, lymphoid pro-inflammatory CD8(+) IL-17A(+) T cells displayed a decreased capacity of cytokine production, which was related to disease activity in early RA patients. In addition, a decreased frequency of regulatory CD8(+) IL-10(+) T cells in peripheral blood was also related to disease activity in early RA patients. Our results suggest that different CD8(+) T-cell subsets are affected already during the earliest phases of systemic autoimmunity
Original languageEnglish
Pages (from-to)UNSP e67
JournalClinical & translational immunology
Volume5
Issue number4
DOIs
Publication statusPublished - 2016

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