Human Milk Antibody Response After Combining Two Different COVID-19 Vaccines: Mix-and-Match

Sien J. Mulleners, Hannah G. Juncker, Marit J. van Gils, Johannes B. van Goudoever, Britt J. van Keulen

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Background: SARS-CoV-2-specific antibodies are secreted into human milk after women are vaccinated against COVID-19, which might protect the breastfed infant. Due to several reports of severe side-effects of the Oxford-AstraZeneca ChAdOx1 (AZD1222) vaccine against COVID-19, some lactating women followed a heterologous vaccination schedule consisting of the first dose of AZD1222 and a second dose of an mRNA-based vaccine. However, it is unclear whether this generates a significant SARS-CoV-2-specific antibody response in human milk. Main Issue: To quantify the SARS-CoV-2-specific antibody response in human milk of two lactating women receiving a heterologous vaccination schedules: AZD1222 and mRNA-based vaccine (Pfizer-BioNTech [BNT162b2] and Moderna [mRNA-1273]). Management: Both participants collected 16 samples of human milk longitudinally. SARS-CoV-2-specific Immunoglobulin A was measured using an enzyme-linked immunosorbent assay. Conclusion: Based on our results, it could be suggested that heterologous vaccination with AZD1222 and an mRNA-based vaccine can elicit a significant SARS-CoV-2 specific IgA response in human milk.
Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalJournal of human lactation
Volume38
Issue number3
Early online date2022
DOIs
Publication statusPublished - Aug 2022

Keywords

  • COVID-19
  • antibody response
  • breastfeeding
  • case study
  • heterologous vaccination regimen COVID-19
  • human milk
  • lactation
  • mix-and-match COVID-19 vaccination
  • vaccination

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