Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

Jochem H. Bernink; Charlotte P. Peters; Marius Munneke; Anje A. te Velde; Sybren L. Meijer; Kees Weijer; Hulda S. Hreggvidsdottir; Sigrid E. Heinsbroek; Nicolas Legrand; Christianne J. Buskens; Willem A. Bemelman; Jenny M. Mjösberg; Hergen Spits

doi:https://doi.org/10.1038/ni.2534

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

Jochem H. Bernink, Charlotte P. Peters, Marius Munneke, Anje A. te Velde, Sybren L. Meijer, Kees Weijer, Hulda S. Hreggvidsdottir, Sigrid E. Heinsbroek, Nicolas Legrand, Christianne J. Buskens, Willem A. Bemelman, Jenny M. Mjösberg, Hergen Spits

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Abstract

Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets T(H)2, T(H)17 and T(H)22. Here we describe a distinct ILC subset similar to T(H)1 cells, which we call 'ILC1'. ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-γ (IFN-γ). ILC1 cells were distinct from natural killer (NK) cells as they lacked perforin, granzyme B and the NK cell markers CD56, CD16 and CD94, and could develop from RORγt(+) ILC3 under the influence of IL-12. The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing ILC1 cells in the pathogenesis of gut mucosal inflammation

Original language	English
Pages (from-to)	221-229
Journal	Nature immunology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1038/ni.2534
Publication status	Published - 2013

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https://doi.org/10.1038/ni.2534

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@article{0815d928b07a4ab8991a1eaddc69c2d9,

title = "Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues",

abstract = "Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets T(H)2, T(H)17 and T(H)22. Here we describe a distinct ILC subset similar to T(H)1 cells, which we call 'ILC1'. ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-γ (IFN-γ). ILC1 cells were distinct from natural killer (NK) cells as they lacked perforin, granzyme B and the NK cell markers CD56, CD16 and CD94, and could develop from RORγt(+) ILC3 under the influence of IL-12. The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing ILC1 cells in the pathogenesis of gut mucosal inflammation",

author = "Bernink, {Jochem H.} and Peters, {Charlotte P.} and Marius Munneke and {te Velde}, {Anje A.} and Meijer, {Sybren L.} and Kees Weijer and Hreggvidsdottir, {Hulda S.} and Heinsbroek, {Sigrid E.} and Nicolas Legrand and Buskens, {Christianne J.} and Bemelman, {Willem A.} and Mj{\"o}sberg, {Jenny M.} and Hergen Spits",

year = "2013",

doi = "https://doi.org/10.1038/ni.2534",

language = "English",

volume = "14",

pages = "221--229",

journal = "Nature immunology",

issn = "1529-2908",

publisher = "Nature Publishing Group",

number = "3",

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TY - JOUR

T1 - Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

AU - Bernink, Jochem H.

AU - Peters, Charlotte P.

AU - Munneke, Marius

AU - te Velde, Anje A.

AU - Meijer, Sybren L.

AU - Weijer, Kees

AU - Hreggvidsdottir, Hulda S.

AU - Heinsbroek, Sigrid E.

AU - Legrand, Nicolas

AU - Buskens, Christianne J.

AU - Bemelman, Willem A.

AU - Mjösberg, Jenny M.

AU - Spits, Hergen

PY - 2013

Y1 - 2013

N2 - Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets T(H)2, T(H)17 and T(H)22. Here we describe a distinct ILC subset similar to T(H)1 cells, which we call 'ILC1'. ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-γ (IFN-γ). ILC1 cells were distinct from natural killer (NK) cells as they lacked perforin, granzyme B and the NK cell markers CD56, CD16 and CD94, and could develop from RORγt(+) ILC3 under the influence of IL-12. The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing ILC1 cells in the pathogenesis of gut mucosal inflammation

AB - Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets T(H)2, T(H)17 and T(H)22. Here we describe a distinct ILC subset similar to T(H)1 cells, which we call 'ILC1'. ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-γ (IFN-γ). ILC1 cells were distinct from natural killer (NK) cells as they lacked perforin, granzyme B and the NK cell markers CD56, CD16 and CD94, and could develop from RORγt(+) ILC3 under the influence of IL-12. The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing ILC1 cells in the pathogenesis of gut mucosal inflammation

U2 - https://doi.org/10.1038/ni.2534

DO - https://doi.org/10.1038/ni.2534

M3 - Article

C2 - 23334791

SN - 1529-2908

VL - 14

SP - 221

EP - 229

JO - Nature immunology

JF - Nature immunology

IS - 3

ER -