TY - JOUR
T1 - Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes
AU - Remmerswaal, Ester B. M.
AU - Havenith, Simone H. C.
AU - Idu, Mirza M.
AU - van Leeuwen, Ester M. M.
AU - van Donselaar, Karlijn A. M. I.
AU - van der Bom-Baylon, Nelly
AU - Bemelman, Fréderike J.
AU - van Lier, René A. W.
AU - ten Berge, Ineke J. M.
PY - 2012
Y1 - 2012
N2 - It is believed that the size of the CD8(+) T-cell pool is fixed and that with every new viral challenge, the size of the preexisting memory-cell population shrinks to make way for the new virus-specific cells. CMV-seropositive individuals have high numbers of CMV-specific resting-effector type CD8(+) T cells in their peripheral blood (PB). This prompted us to investigate whether CMV infection limits immunologic space at sites where immune reactions are initiated, such as in the lymph nodes (LNs). LN and paired PB samples were analyzed for CMV-, EBV-, and influenza-specific CD8(+) T cells. In marked contrast to blood, LNs contained significantly lower numbers of CX3CR1-expressing effector-type CD8(+) T cells, whereas the CMV-specific cells that were found in the LNs resembled polyfunctional memory-type cells. In contrast, EBV- and influenza-specific CD8(+) T cells were highly similar between PB and LNs both in number and function. Therefore, it is unlikely that CMV-specific CD8(+) T cells in the LNs restrain the immunologic space of other virus-specific cells. (Blood.2012;119(7):1702-1712)
AB - It is believed that the size of the CD8(+) T-cell pool is fixed and that with every new viral challenge, the size of the preexisting memory-cell population shrinks to make way for the new virus-specific cells. CMV-seropositive individuals have high numbers of CMV-specific resting-effector type CD8(+) T cells in their peripheral blood (PB). This prompted us to investigate whether CMV infection limits immunologic space at sites where immune reactions are initiated, such as in the lymph nodes (LNs). LN and paired PB samples were analyzed for CMV-, EBV-, and influenza-specific CD8(+) T cells. In marked contrast to blood, LNs contained significantly lower numbers of CX3CR1-expressing effector-type CD8(+) T cells, whereas the CMV-specific cells that were found in the LNs resembled polyfunctional memory-type cells. In contrast, EBV- and influenza-specific CD8(+) T cells were highly similar between PB and LNs both in number and function. Therefore, it is unlikely that CMV-specific CD8(+) T cells in the LNs restrain the immunologic space of other virus-specific cells. (Blood.2012;119(7):1702-1712)
U2 - https://doi.org/10.1182/blood-2011-09-381574
DO - https://doi.org/10.1182/blood-2011-09-381574
M3 - Article
C2 - 22207739
SN - 0006-4971
VL - 119
SP - 1702
EP - 1712
JO - Blood
JF - Blood
IS - 7
ER -