Human αB-crystallin (CRYA2) gene mapped to chromosome 11q12-q23

Ruud H. Brakenhoff; Ad H.M.Geurts van Kessel; Margot Oldenburg; Jules T. Wijnen; Hans Bloemendal; P. Meera Khan; John G.G. Schoenmakers

doi:https://doi.org/10.1007/BF00193203

Human αB-crystallin (CRYA2) gene mapped to chromosome 11q12-q23

Ruud H. Brakenhoff, Ad H.M.Geurts van Kessel, Margot Oldenburg, Jules T. Wijnen, Hans Bloemendal, P. Meera Khan, John G.G. Schoenmakers

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21 Citations (Scopus)

Abstract

The αB-crystallin gene (CRYA2) encodes the abundant lens protein αB-crystallin. A panel of human/ rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster αB-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q₁₂-11q₂₃.

Original language	English
Pages (from-to)	237-240
Number of pages	4
Journal	Human genetics
Volume	85
Issue number	2
DOIs	https://doi.org/10.1007/BF00193203
Publication status	Published - Jul 1990

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title = "Human αB-crystallin (CRYA2) gene mapped to chromosome 11q12-q23",

abstract = "The αB-crystallin gene (CRYA2) encodes the abundant lens protein αB-crystallin. A panel of human/ rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster αB-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q12-11q23.",

author = "Brakenhoff, {Ruud H.} and {van Kessel}, {Ad H.M.Geurts} and Margot Oldenburg and Wijnen, {Jules T.} and Hans Bloemendal and Khan, {P. Meera} and Schoenmakers, {John G.G.}",

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month = jul,

doi = "https://doi.org/10.1007/BF00193203",

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AU - Brakenhoff, Ruud H.

AU - van Kessel, Ad H.M.Geurts

AU - Oldenburg, Margot

AU - Wijnen, Jules T.

AU - Bloemendal, Hans

AU - Khan, P. Meera

AU - Schoenmakers, John G.G.

PY - 1990/7

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N2 - The αB-crystallin gene (CRYA2) encodes the abundant lens protein αB-crystallin. A panel of human/ rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster αB-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q12-11q23.

AB - The αB-crystallin gene (CRYA2) encodes the abundant lens protein αB-crystallin. A panel of human/ rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster αB-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q12-11q23.

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VL - 85

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JO - Human genetics

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Human αB-crystallin (CRYA2) gene mapped to chromosome 11q12-q23

Abstract

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