TY - JOUR
T1 - Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies
AU - Eppink, Berina
AU - Krawczyk, Przemek M.
AU - Stap, Jan
AU - Kanaar, Roland
PY - 2012
Y1 - 2012
N2 - Local hyperthermia is an effective treatment modality to augment radio-and chemotherapy-based anti-cancer treatments. Although the effect of hyperthermia is pleotropic, recent experiments revealed that homologous recombination, a pathway of DNA repair, is directly inhibited by hyperthermia. The hyperthermia-induced DNA repair deficiency is enhanced by inhibitors of the cellular heat-shock response. Taken together, these results provide the rationale for the development of novel anti-cancer therapies that combine hyperthermia-induced homologous recombination deficiency with the systemic administration of drugs that specifically affect the viability of homologous recombination deficient cells and/or inhibit the heat-shock response, to locally sensitise cancer cells to DNA damaging agents
AB - Local hyperthermia is an effective treatment modality to augment radio-and chemotherapy-based anti-cancer treatments. Although the effect of hyperthermia is pleotropic, recent experiments revealed that homologous recombination, a pathway of DNA repair, is directly inhibited by hyperthermia. The hyperthermia-induced DNA repair deficiency is enhanced by inhibitors of the cellular heat-shock response. Taken together, these results provide the rationale for the development of novel anti-cancer therapies that combine hyperthermia-induced homologous recombination deficiency with the systemic administration of drugs that specifically affect the viability of homologous recombination deficient cells and/or inhibit the heat-shock response, to locally sensitise cancer cells to DNA damaging agents
U2 - https://doi.org/10.3109/02656736.2012.695427
DO - https://doi.org/10.3109/02656736.2012.695427
M3 - Article
C2 - 22834701
SN - 0265-6736
VL - 28
SP - 509
EP - 517
JO - International journal of hyperthermia
JF - International journal of hyperthermia
IS - 6
ER -