TY - JOUR
T1 - Hypothalamic-Pituitary and Other Endocrine Surveillance Among Childhood Cancer Survivors
AU - van Iersel, Laura
AU - Mulder, Renee L.
AU - Denzer, Christian
AU - Cohen, Laurie E.
AU - Spoudeas, Helen A.
AU - Meacham, Lillian R.
AU - Sugden, Elaine
AU - Schouten-van Meeteren, Antoinette Y. N.
AU - Hoving, Eelco W.
AU - Packer, Roger J.
AU - Armstrong, Gregory T.
AU - Mostoufi-Moab, Sogol
AU - Stades, Aline M.
AU - van Vuurden, Dannis
AU - Janssens, Geert O.
AU - Thomas-Teinturier, C. cile
AU - Murray, Robert D.
AU - di Iorgi, Natascia
AU - Neggers, Sebastian J. C. M. M.
AU - Thompson, Joel
AU - Toogood, Andrew A.
AU - Gleeson, Helena
AU - Follin, Cecilia
AU - Bardi, Edit
AU - Torno, Lilibeth
AU - Patterson, Briana
AU - Morsellino, Vera
AU - Sommer, Grit
AU - Clement, Sarah C.
AU - Srivastava, Deokumar
AU - Kiserud, Cecilie E.
AU - Fernandez, Alberto
AU - Scheinemann, Katrin
AU - Raman, Sripriya
AU - Yuen, Kevin C. J.
AU - Wallace, W. Hamish
AU - Constine, Louis S.
AU - Skinner, Roderick
AU - Hudson, Melissa M.
AU - Kremer, Leontien C. M.
AU - Chemaitilly, Wassim
AU - van Santen, Hanneke M.
N1 - Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2022/9/26
Y1 - 2022/9/26
N2 - Endocrine disorders in survivors of childhood, adolescent, and young adult (CAYA) cancers are associated with substantial adverse physical and psychosocial effects. To improve appropriate and timely endocrine screening and referral to a specialist, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) aims to develop evidence and expert consensus-based guidelines for healthcare providers that harmonize recommendations for surveillance of endocrine disorders in CAYA cancer survivors. Existing IGHG surveillance recommendations for premature ovarian insufficiency, gonadotoxicity in males, fertility preservation, and thyroid cancer are summarized. For hypothalamic-pituitary (HP) dysfunction, new surveillance recommendations were formulated by a guideline panel consisting of 42 interdisciplinary international experts. A systematic literature search was performed in MEDLINE (through PubMed) for clinically relevant questions concerning HP dysfunction. Literature was screened for eligibility. Recommendations were formulated by drawing conclusions from quality assessment of all evidence, considering the potential benefits of early detection and appropriate management. Healthcare providers should be aware that CAYA cancer survivors have an increased risk for endocrine disorders, including HP dysfunction. Regular surveillance with clinical history, anthropomorphic measures, physical examination, and laboratory measurements is recommended in at-risk survivors. When endocrine disorders are suspected, healthcare providers should proceed with timely referrals to specialized services. These international evidence-based recommendations for surveillance of endocrine disorders in CAYA cancer survivors inform healthcare providers and highlight the need for long-term endocrine follow-up care in subgroups of survivors and elucidate opportunities for further research.
AB - Endocrine disorders in survivors of childhood, adolescent, and young adult (CAYA) cancers are associated with substantial adverse physical and psychosocial effects. To improve appropriate and timely endocrine screening and referral to a specialist, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) aims to develop evidence and expert consensus-based guidelines for healthcare providers that harmonize recommendations for surveillance of endocrine disorders in CAYA cancer survivors. Existing IGHG surveillance recommendations for premature ovarian insufficiency, gonadotoxicity in males, fertility preservation, and thyroid cancer are summarized. For hypothalamic-pituitary (HP) dysfunction, new surveillance recommendations were formulated by a guideline panel consisting of 42 interdisciplinary international experts. A systematic literature search was performed in MEDLINE (through PubMed) for clinically relevant questions concerning HP dysfunction. Literature was screened for eligibility. Recommendations were formulated by drawing conclusions from quality assessment of all evidence, considering the potential benefits of early detection and appropriate management. Healthcare providers should be aware that CAYA cancer survivors have an increased risk for endocrine disorders, including HP dysfunction. Regular surveillance with clinical history, anthropomorphic measures, physical examination, and laboratory measurements is recommended in at-risk survivors. When endocrine disorders are suspected, healthcare providers should proceed with timely referrals to specialized services. These international evidence-based recommendations for surveillance of endocrine disorders in CAYA cancer survivors inform healthcare providers and highlight the need for long-term endocrine follow-up care in subgroups of survivors and elucidate opportunities for further research.
KW - childhood cancer survivor
KW - clinical practice guidelines
KW - endocrine complications
KW - endocrine late effects
KW - radiotherapy late effects
UR - http://www.scopus.com/inward/record.url?scp=85135039606&partnerID=8YFLogxK
U2 - https://doi.org/10.1210/endrev/bnab040
DO - https://doi.org/10.1210/endrev/bnab040
M3 - Article
C2 - 34962573
SN - 0163-769X
VL - 43
SP - 794
EP - 823
JO - Endocrine reviews
JF - Endocrine reviews
IS - 5
ER -