Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections

Le Van Tan, H. Rogier van Doorn, Ho Dang Trung Nghia, Tran Thi Hong Chau, Le Thi Phuong Tu, Michel de Vries, Marta Canuti, Martin Deijs, Maarten F. Jebbink, Stephen Baker, Juliet E. Bryant, Nguyen Thi Tham, Nguyen Thi Thuy Chinh Bkrong, Maciej F. Boni, Tran Quoc Loi, Le Thi Phuong, Joost T. P. Verhoeven, Martin Crusat, Rienk E. Jeeninga, Constance SchultszNguyen Van Vinh Chau, Tran Tinh Hien, Lia van der Hoek, Jeremy Farrar, Menno D. de Jong

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101 Citations (Scopus)


Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus
Original languageEnglish
Pages (from-to)e00231-e00213
Issue number3
Publication statusPublished - 2013

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