Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections

Le Van Tan; H. Rogier van Doorn; Ho Dang Trung Nghia; Tran Thi Hong Chau; Le Thi Phuong Tu; Michel de Vries; Marta Canuti; Martin Deijs; Maarten F. Jebbink; Stephen Baker; Juliet E. Bryant; Nguyen Thi Tham; Nguyen Thi Thuy Chinh Bkrong; Maciej F. Boni; Tran Quoc Loi; Le Thi Phuong; Joost T. P. Verhoeven; Martin Crusat; Rienk E. Jeeninga; Constance Schultsz; Nguyen Van Vinh Chau; Tran Tinh Hien; Lia van der Hoek; Jeremy Farrar; Menno D. de Jong

doi:https://doi.org/10.1128/mBio.00231-13

Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections

Le Van Tan, H. Rogier van Doorn, Ho Dang Trung Nghia, Tran Thi Hong Chau, Le Thi Phuong Tu, Michel de Vries, Marta Canuti, Martin Deijs, Maarten F. Jebbink, Stephen Baker, Juliet E. Bryant, Nguyen Thi Tham, Nguyen Thi Thuy Chinh Bkrong, Maciej F. Boni, Tran Quoc Loi, Le Thi Phuong, Joost T. P. Verhoeven, Martin Crusat, Rienk E. Jeeninga, Constance SchultszNguyen Van Vinh Chau, Tran Tinh Hien, Lia van der Hoek, Jeremy Farrar, Menno D. de Jong

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus

Original language	English
Pages (from-to)	e00231-e00213
Journal	MBio
Volume	4
Issue number	3
DOIs	https://doi.org/10.1128/mBio.00231-13
Publication status	Published - 2013

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https://doi.org/10.1128/mBio.00231-13

Cite this

Tan, L. V., van Doorn, H. R., Nghia, H. D. T., Chau, T. T. H., Tu, L. T. P., de Vries, M., Canuti, M., Deijs, M., Jebbink, M. F., Baker, S., Bryant, J. E., Tham, N. T., Bkrong, N. T. T. C., Boni, M. F., Loi, T. Q., Phuong, L. T., Verhoeven, J. T. P., Crusat, M., Jeeninga, R. E., ... de Jong, M. D. (2013). Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. MBio, 4(3), e00231-e00213. https://doi.org/10.1128/mBio.00231-13

@article{da84772a17774e66a5f86de2aedfd89c,

title = "Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections",

abstract = "Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus",

author = "Tan, {Le Van} and {van Doorn}, {H. Rogier} and Nghia, {Ho Dang Trung} and Chau, {Tran Thi Hong} and Tu, {Le Thi Phuong} and {de Vries}, Michel and Marta Canuti and Martin Deijs and Jebbink, {Maarten F.} and Stephen Baker and Bryant, {Juliet E.} and Tham, {Nguyen Thi} and Bkrong, {Nguyen Thi Thuy Chinh} and Boni, {Maciej F.} and Loi, {Tran Quoc} and Phuong, {Le Thi} and Verhoeven, {Joost T. P.} and Martin Crusat and Jeeninga, {Rienk E.} and Constance Schultsz and Chau, {Nguyen Van Vinh} and Hien, {Tran Tinh} and {van der Hoek}, Lia and Jeremy Farrar and {de Jong}, {Menno D.}",

year = "2013",

doi = "https://doi.org/10.1128/mBio.00231-13",

language = "English",

volume = "4",

pages = "e00231--e00213",

journal = "MBio",

issn = "2150-7511",

publisher = "American Society for Microbiology",

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Tan, LV, van Doorn, HR, Nghia, HDT, Chau, TTH, Tu, LTP, de Vries, M, Canuti, M, Deijs, M, Jebbink, MF, Baker, S, Bryant, JE, Tham, NT, Bkrong, NTTC, Boni, MF, Loi, TQ, Phuong, LT, Verhoeven, JTP, Crusat, M, Jeeninga, RE, Schultsz, C, Chau, NVV, Hien, TT, van der Hoek, L, Farrar, J & de Jong, MD 2013, 'Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections', MBio, vol. 4, no. 3, pp. e00231-e00213. https://doi.org/10.1128/mBio.00231-13

TY - JOUR

T1 - Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections

AU - Tan, Le Van

AU - van Doorn, H. Rogier

AU - Nghia, Ho Dang Trung

AU - Chau, Tran Thi Hong

AU - Tu, Le Thi Phuong

AU - de Vries, Michel

AU - Canuti, Marta

AU - Deijs, Martin

AU - Jebbink, Maarten F.

AU - Baker, Stephen

AU - Bryant, Juliet E.

AU - Tham, Nguyen Thi

AU - Bkrong, Nguyen Thi Thuy Chinh

AU - Boni, Maciej F.

AU - Loi, Tran Quoc

AU - Phuong, Le Thi

AU - Verhoeven, Joost T. P.

AU - Crusat, Martin

AU - Jeeninga, Rienk E.

AU - Schultsz, Constance

AU - Chau, Nguyen Van Vinh

AU - Hien, Tran Tinh

AU - van der Hoek, Lia

AU - Farrar, Jeremy

AU - de Jong, Menno D.

PY - 2013

Y1 - 2013

N2 - Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus

AB - Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus

U2 - https://doi.org/10.1128/mBio.00231-13

DO - https://doi.org/10.1128/mBio.00231-13

M3 - Article

C2 - 23781068

SN - 2150-7511

VL - 4

SP - e00231-e00213

JO - MBio

JF - MBio

IS - 3

ER -