TY - JOUR
T1 - Identification of a novel stereotypic IGHV4-59/IGHJ5-encoded B-cell receptor subset expressed by various B-cell lymphomas with high affinity rheumatoid factor activity
AU - Bende, Richard J.
AU - Janssen, Jerry
AU - Wormhoudt, Thera A. M.
AU - Wagner, Koen
AU - Guikema, Jeroen E. J.
AU - van Noesel, Carel J. M.
PY - 2016
Y1 - 2016
N2 - Subsets of mucosa-associated lymphoid tissue (MALT) lymphoma, splenic marginal zone B-cell lymphoma (MZBCL) and chronic lymphocytic leukemia (CLL) have been identified that express near-identical B-cell receptors (BCRs), strongly suggesting selection by restricted antigenic epitopes. We here report a new IGV mutated stereotypic IGHV4-59/IGHJ5-encoded BCR subset, expressed in hepatitis C virus (HCV)-related B-cell lymphoma, MALT lymphoma and diffuse large B-cell lymphoma (DLBCL). We demonstrate that these mutated stereotypic IGHV4-59/IGHJ5 BCRs are high affinity monoreactive rheumatoid factors (RFs) underscoring the significance of IgG as a major auto-antigen in the pathogenesis of several types of B-cell lymphoma
AB - Subsets of mucosa-associated lymphoid tissue (MALT) lymphoma, splenic marginal zone B-cell lymphoma (MZBCL) and chronic lymphocytic leukemia (CLL) have been identified that express near-identical B-cell receptors (BCRs), strongly suggesting selection by restricted antigenic epitopes. We here report a new IGV mutated stereotypic IGHV4-59/IGHJ5-encoded BCR subset, expressed in hepatitis C virus (HCV)-related B-cell lymphoma, MALT lymphoma and diffuse large B-cell lymphoma (DLBCL). We demonstrate that these mutated stereotypic IGHV4-59/IGHJ5 BCRs are high affinity monoreactive rheumatoid factors (RFs) underscoring the significance of IgG as a major auto-antigen in the pathogenesis of several types of B-cell lymphoma
U2 - https://doi.org/10.3324/haematol.2015.139626
DO - https://doi.org/10.3324/haematol.2015.139626
M3 - Comment/Letter to the editor
C2 - 26858354
VL - 101
SP - e200-e203
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 5
ER -