Introduction: Empirical studies on effective communication for amyloid disclosure in mild cognitive impairment (MCI) are lacking. We aimed to study the impact of six communication strategies. Method: We performed a randomized controlled trial with seven randomly assigned, video-vignette conditions: six emphasizing a communication strategy and one basic condition. All showed a scripted consultation of a neurologist disclosing positive amyloid positron emission tomography (PET) scan results to an MCI patient. Healthy individuals (N = 1017; mean age ± SD 64 ± 8, 808 (79%) female) were instructed to imagine themselves in the video, answered questionnaires assessing information recall, emotional state, and behavioral intentions, and evaluate the physician/information. Results: “Risk best practice” resulted in highest free recall compared to other strategies (P <.05), except “emotional support”. Recall in “emotional support” was better compared to “basic-‘ and elaborate information”(P <.05). “Risk best practice” resulted in the highest uncertainty (P <.001). “Teach-back” and “emotional support” contributed to the highest evaluations (P -values <.01). Conclusion: Risk communication best practices, attending to emotions, and teach-back techniques enhance information recall of amyloid-PET results, and could contribute to positive care evaluations.

Original languageEnglish
Pages (from-to)285-295
Number of pages11
JournalAlzheimer's and Dementia
Issue number1
Early online date2 Apr 2022
Publication statusPublished - Jan 2023


  • MCI
  • amyloid status
  • communication
  • disclosure
  • mild cognitive impairment

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