IDH-Mutant Brain Tumors Hit the Achilles' Heel of Macrophages with R-2-Hydroxyglutarate

Xanthe A. M. H. van Dierendonck; Kyra E. de Goede; Jan Van den Bossche

doi:https://doi.org/10.1016/j.trecan.2021.06.003

IDH-Mutant Brain Tumors Hit the Achilles' Heel of Macrophages with R-2-Hydroxyglutarate

Xanthe A. M. H. van Dierendonck, Kyra E. de Goede, Jan Van den Bossche

Research output: Contribution to journal › Editorial › Academic › peer-review

6 Citations (Scopus)

Abstract

Isocitrate dehydrogenase (IDH) mutations produce high levels of the ‘oncometabolite’ R-2-hydroxyglutarate (R-2-HG) and play a key role in the initiation and progression of glioma tumors in the brain. A recent study in Nature Cancer by Friedrich et al. describes how IDH-mutant-derived R-2-HG elicits an immunosuppressive phenotype in glioma-associated macrophages. As such, the authors uncovered a new vulnerability that can be exploited for therapy.

Original language	English
Pages (from-to)	666-667
Number of pages	2
Journal	Trends in Cancer
Volume	7
Issue number	8
Early online date	2021
DOIs	https://doi.org/10.1016/j.trecan.2021.06.003
Publication status	Published - Aug 2021

Keywords

R-2-hydroxyglutarate (R-2-HG)
immunometabolism
immunosuppression
immunotherapy
isocitrate dehydrogenase (IDH)-mutant gliomas
tumor-associated macrophages

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https://doi.org/10.1016/j.trecan.2021.06.003

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title = "IDH-Mutant Brain Tumors Hit the Achilles' Heel of Macrophages with R-2-Hydroxyglutarate",

abstract = "Isocitrate dehydrogenase (IDH) mutations produce high levels of the {\textquoteleft}oncometabolite{\textquoteright} R-2-hydroxyglutarate (R-2-HG) and play a key role in the initiation and progression of glioma tumors in the brain. A recent study in Nature Cancer by Friedrich et al. describes how IDH-mutant-derived R-2-HG elicits an immunosuppressive phenotype in glioma-associated macrophages. As such, the authors uncovered a new vulnerability that can be exploited for therapy.",

keywords = "R-2-hydroxyglutarate (R-2-HG), immunometabolism, immunosuppression, immunotherapy, isocitrate dehydrogenase (IDH)-mutant gliomas, tumor-associated macrophages",

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doi = "https://doi.org/10.1016/j.trecan.2021.06.003",

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T1 - IDH-Mutant Brain Tumors Hit the Achilles' Heel of Macrophages with R-2-Hydroxyglutarate

AU - van Dierendonck, Xanthe A. M. H.

AU - de Goede, Kyra E.

AU - Van den Bossche, Jan

PY - 2021/8

Y1 - 2021/8

N2 - Isocitrate dehydrogenase (IDH) mutations produce high levels of the ‘oncometabolite’ R-2-hydroxyglutarate (R-2-HG) and play a key role in the initiation and progression of glioma tumors in the brain. A recent study in Nature Cancer by Friedrich et al. describes how IDH-mutant-derived R-2-HG elicits an immunosuppressive phenotype in glioma-associated macrophages. As such, the authors uncovered a new vulnerability that can be exploited for therapy.

AB - Isocitrate dehydrogenase (IDH) mutations produce high levels of the ‘oncometabolite’ R-2-hydroxyglutarate (R-2-HG) and play a key role in the initiation and progression of glioma tumors in the brain. A recent study in Nature Cancer by Friedrich et al. describes how IDH-mutant-derived R-2-HG elicits an immunosuppressive phenotype in glioma-associated macrophages. As such, the authors uncovered a new vulnerability that can be exploited for therapy.

KW - R-2-hydroxyglutarate (R-2-HG)

KW - immunometabolism

KW - immunosuppression

KW - immunotherapy

KW - isocitrate dehydrogenase (IDH)-mutant gliomas

KW - tumor-associated macrophages

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IDH-Mutant Brain Tumors Hit the Achilles' Heel of Macrophages with R-2-Hydroxyglutarate

Abstract

Keywords

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