Imaging in musculoskeletal, metabolic, endocrinological, and pediatric clinical trials

Colin G. Miller, Hui Jing Yu, Cornelis Van Kuijk

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


Clinical trials in skeletal pathology are abundant and comprise predominantly of trials in osteoporosis, rheumatoid arthritis, osteoarthritis, fracture healing, and bone marrow disease, including genetic disorders of the skeletal system predominantly in pediatric populations. Furthermore, many metabolic and endocrinological syndromes also affect the musculoskeletal system. Radiological end points in clinical trials for the evaluation of the musculoskeletal system are numerous and have a unique set of challenges which are usually disease specific. The imaging modalities employed for these end points include conventional radiography, ultrasound, computed tomography, dual X-ray absorptiometry, magnetic resonance imaging, and bone scintigraphy. This chapter will present the key disease areas, the imaging requirements, the characteristics, including the challenge of quantitative versus qualitative assessment, and the use of imaging as a biomarker in these diseases.

Original languageEnglish
Title of host publicationMedical Imaging in Clinical Trials
PublisherSpringer-Verlag London Ltd
Number of pages15
ISBN (Electronic)9781848827103
ISBN (Print)1848827091, 9781848827097
Publication statusPublished - 1 Jun 2013


  • Bone marrow disease
  • Fracture healing
  • Osteoarthritis
  • Osteoporosis
  • Pediatric bone diseases
  • Rheumatoid arthritis

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