An imbalance between uracil and cytosine ribonucleotide pools was observed in rat pheochromocytoma PC-12 cells when compared with adrenal medulla tissue. Moreover, this imbalance is proliferation-rate independent. The stage of differentiation and differences due to culturing conditions could not be linked to the observed imbalance. Therefore, we postulate that the imbalance between these ribonucleotide pools of PC-12 cells is associated with transformation.
|Number of pages||5|
|Journal||Clinical Chemistry and Enzymology Communications|
|Publication status||Published - 1993|
- Adrenal medulla