Imbalance between the pyrimidine ribonucleotide pools of rat pheochromocytoma PC-12 cells

R. J. Slingerland, J. M. Bodlaender, H. Van Lenthe, A. B.P. Van Kuilenburg, A. H. Van Gennip

Research output: Contribution to journalArticleAcademicpeer-review


An imbalance between uracil and cytosine ribonucleotide pools was observed in rat pheochromocytoma PC-12 cells when compared with adrenal medulla tissue. Moreover, this imbalance is proliferation-rate independent. The stage of differentiation and differences due to culturing conditions could not be linked to the observed imbalance. Therefore, we postulate that the imbalance between these ribonucleotide pools of PC-12 cells is associated with transformation.

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalClinical Chemistry and Enzymology Communications
Issue number4-6
Publication statusPublished - 1993


  • Adrenal medulla
  • Catecholamines
  • PC-12
  • Pheochromocytoma
  • Pyrimidines
  • Ribonucleotides

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