Imbalance between the pyrimidine ribonucleotide pools of rat pheochromocytoma PC-12 cells

R. J. Slingerland; J. M. Bodlaender; H. Van Lenthe; A. B.P. Van Kuilenburg; A. H. Van Gennip

Imbalance between the pyrimidine ribonucleotide pools of rat pheochromocytoma PC-12 cells

R. J. Slingerland, J. M. Bodlaender, H. Van Lenthe, A. B.P. Van Kuilenburg, A. H. Van Gennip

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

An imbalance between uracil and cytosine ribonucleotide pools was observed in rat pheochromocytoma PC-12 cells when compared with adrenal medulla tissue. Moreover, this imbalance is proliferation-rate independent. The stage of differentiation and differences due to culturing conditions could not be linked to the observed imbalance. Therefore, we postulate that the imbalance between these ribonucleotide pools of PC-12 cells is associated with transformation.

Original language	English
Pages (from-to)	315-319
Number of pages	5
Journal	Clinical Chemistry and Enzymology Communications
Volume	5
Issue number	4-6
Publication status	Published - 1993

Keywords

Adrenal medulla
Catecholamines
PC-12
Pheochromocytoma
Pyrimidines
Ribonucleotides

Cite this

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abstract = "An imbalance between uracil and cytosine ribonucleotide pools was observed in rat pheochromocytoma PC-12 cells when compared with adrenal medulla tissue. Moreover, this imbalance is proliferation-rate independent. The stage of differentiation and differences due to culturing conditions could not be linked to the observed imbalance. Therefore, we postulate that the imbalance between these ribonucleotide pools of PC-12 cells is associated with transformation.",

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AU - Slingerland, R. J.

AU - Bodlaender, J. M.

AU - Van Lenthe, H.

AU - Van Kuilenburg, A. B.P.

AU - Van Gennip, A. H.

PY - 1993

Y1 - 1993

N2 - An imbalance between uracil and cytosine ribonucleotide pools was observed in rat pheochromocytoma PC-12 cells when compared with adrenal medulla tissue. Moreover, this imbalance is proliferation-rate independent. The stage of differentiation and differences due to culturing conditions could not be linked to the observed imbalance. Therefore, we postulate that the imbalance between these ribonucleotide pools of PC-12 cells is associated with transformation.

AB - An imbalance between uracil and cytosine ribonucleotide pools was observed in rat pheochromocytoma PC-12 cells when compared with adrenal medulla tissue. Moreover, this imbalance is proliferation-rate independent. The stage of differentiation and differences due to culturing conditions could not be linked to the observed imbalance. Therefore, we postulate that the imbalance between these ribonucleotide pools of PC-12 cells is associated with transformation.

KW - Adrenal medulla

KW - Catecholamines

KW - PC-12

KW - Pheochromocytoma

KW - Pyrimidines

KW - Ribonucleotides

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M3 - Article

SN - 0892-2187

VL - 5

SP - 315

EP - 319

JO - Clinical Chemistry and Enzymology Communications

JF - Clinical Chemistry and Enzymology Communications

IS - 4-6

ER -

Imbalance between the pyrimidine ribonucleotide pools of rat pheochromocytoma PC-12 cells

Abstract

Keywords

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