Immune activation modulates hematopoiesis through interactions between CD27 and CD70

Martijn A. Nolte; Ramon Arens; Ronald van Os; Michiel van Oosterwijk; Berend Hooibrink; René A. W. van Lier; Marinus H. J. van Oers

doi:https://doi.org/10.1038/ni1174

Immune activation modulates hematopoiesis through interactions between CD27 and CD70

Martijn A. Nolte, Ramon Arens, Ronald van Os, Michiel van Oosterwijk, Berend Hooibrink, René A. W. van Lier, Marinus H. J. van Oers

Research output: Contribution to journal › Article › Academic › peer-review

54 Citations (Scopus)

Abstract

The differentiation of hematopoietic stem cells into mature blood cell lineages is tightly regulated. Here we report that CD27, which is expressed on stem and early progenitor cells in bone marrow, can be important in this process. Deletion of CD27 increased the myeloid colony-forming potential of stem and early progenitor cells and enhanced B lymphoid reconstitutive capacity in competitive transplantation experiments. Conversely, stimulation of CD27(+) progenitor cells with CD70, the unique ligand for CD27, inhibited colony-forming potential in vitro and lymphocyte outgrowth in vivo. As CD70 is expressed only on activated immune cells, we suggest that CD27 triggering on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation

Original language	English
Pages (from-to)	412-418
Journal	Nature immunology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1038/ni1174
Publication status	Published - 2005

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https://doi.org/10.1038/ni1174

Cite this

@article{d25ee113d47f465ea676bd8ffa6434e0,

title = "Immune activation modulates hematopoiesis through interactions between CD27 and CD70",

abstract = "The differentiation of hematopoietic stem cells into mature blood cell lineages is tightly regulated. Here we report that CD27, which is expressed on stem and early progenitor cells in bone marrow, can be important in this process. Deletion of CD27 increased the myeloid colony-forming potential of stem and early progenitor cells and enhanced B lymphoid reconstitutive capacity in competitive transplantation experiments. Conversely, stimulation of CD27(+) progenitor cells with CD70, the unique ligand for CD27, inhibited colony-forming potential in vitro and lymphocyte outgrowth in vivo. As CD70 is expressed only on activated immune cells, we suggest that CD27 triggering on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation",

author = "Nolte, {Martijn A.} and Ramon Arens and {van Os}, Ronald and {van Oosterwijk}, Michiel and Berend Hooibrink and {van Lier}, {Ren{\'e} A. W.} and {van Oers}, {Marinus H. J.}",

year = "2005",

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AU - Nolte, Martijn A.

AU - Arens, Ramon

AU - van Os, Ronald

AU - van Oosterwijk, Michiel

AU - Hooibrink, Berend

AU - van Lier, René A. W.

AU - van Oers, Marinus H. J.

PY - 2005

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N2 - The differentiation of hematopoietic stem cells into mature blood cell lineages is tightly regulated. Here we report that CD27, which is expressed on stem and early progenitor cells in bone marrow, can be important in this process. Deletion of CD27 increased the myeloid colony-forming potential of stem and early progenitor cells and enhanced B lymphoid reconstitutive capacity in competitive transplantation experiments. Conversely, stimulation of CD27(+) progenitor cells with CD70, the unique ligand for CD27, inhibited colony-forming potential in vitro and lymphocyte outgrowth in vivo. As CD70 is expressed only on activated immune cells, we suggest that CD27 triggering on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation

AB - The differentiation of hematopoietic stem cells into mature blood cell lineages is tightly regulated. Here we report that CD27, which is expressed on stem and early progenitor cells in bone marrow, can be important in this process. Deletion of CD27 increased the myeloid colony-forming potential of stem and early progenitor cells and enhanced B lymphoid reconstitutive capacity in competitive transplantation experiments. Conversely, stimulation of CD27(+) progenitor cells with CD70, the unique ligand for CD27, inhibited colony-forming potential in vitro and lymphocyte outgrowth in vivo. As CD70 is expressed only on activated immune cells, we suggest that CD27 triggering on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation

U2 - https://doi.org/10.1038/ni1174

DO - https://doi.org/10.1038/ni1174

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EP - 418

JO - Nature immunology

JF - Nature immunology

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