TY - JOUR
T1 - Immunogenicity of an Additional mRNA-1273 SARS-CoV-2 Vaccination in People With HIV With Hyporesponse After Primary Vaccination
AU - Jongkees, Marlou J.
AU - Geers, Daryl
AU - Hensley, Kathryn S.
AU - Huisman, Wesley
AU - GeurtsvanKessel, Corine H.
AU - Bogers, Susanne
AU - Gommers, Lennert
AU - Papageorgiou, Grigorios
AU - Jochems, Simon P.
AU - den Hollander, Jan G.
AU - Schippers, Emile F.
AU - Ammerlaan, Heidi S. M.
AU - Bierman, Wouter F. W.
AU - van der Valk, Marc
AU - Berrevoets, Marvin A. H.
AU - Soetekouw, Robert
AU - Langebeek, Nienke
AU - Bruns, Anke H. W.
AU - Leyten, Eliane M. S.
AU - Sigaloff, Kim C. E.
AU - van Vonderen, Marit G. A.
AU - Delsing, Corine E.
AU - Branger, Judith
AU - Katsikis, Peter D.
AU - Mueller, Yvonne M.
AU - de Vries, Rory D.
AU - Rijnders, Bart J. A.
AU - Brinkman, Kees
AU - Rokx, Casper
AU - Roukens, Anna H. E.
N1 - Funding Information: Financial support. This work was supported by the Netherlands Organization for Health Research and Development (ZonMw) (grant number 10430072010008); and Health∼Holland (grant number EMCLHS20017 to D. G. and R. D. d. V.) cofunded by the PPP Allowance made available by the Health∼Holland, Top Sector Life Sciences and Health, to stimulate public-private partnerships. Publisher Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Background. The COVIH study is a prospective coronavirus disease 2019 (COVID-19) vaccination study in 1154 people with HIV (PWH), of whom 14% showed reduced antibody levels after primary vaccination. We evaluated whether an additional vaccination boosts immune responses in these hyporesponders. Methods. The primary end point was the increase in antibodies 28 days after additional mRNA-1273 vaccination. Secondary end points included neutralizing antibodies, S-specific T-cell and B-cell responses, and reactogenicity. Results. Of the 66 participants, 40 previously received 2 doses ChAdOx1-S, 22 received 2 doses BNT162b2, and 4 received a single dose Ad26.COV2.S. The median age was 63 years (interquartile range [IQR], 60–66), 86% were male, and median CD4+ T-cell count was 650/μL (IQR, 423–941). The mean S1-specific antibody level increased from 35 binding antibody units (BAU)/ mL (95% confidence interval [CI], 24–46) to 4317 BAU/mL (95% CI, 3275–5360) (P < .0001). Of all participants, 97% showed an adequate response and the 45 antibody-negative participants all seroconverted. A significant increase in the proportion of PWH with ancestral S-specific CD4+ T cells (P = .04) and S-specific B cells (P = .02) was observed. Conclusions. An additional mRNA-1273 vaccination induced a robust serological response in 97% of PWH with a hyporesponse after primary vaccination.
AB - Background. The COVIH study is a prospective coronavirus disease 2019 (COVID-19) vaccination study in 1154 people with HIV (PWH), of whom 14% showed reduced antibody levels after primary vaccination. We evaluated whether an additional vaccination boosts immune responses in these hyporesponders. Methods. The primary end point was the increase in antibodies 28 days after additional mRNA-1273 vaccination. Secondary end points included neutralizing antibodies, S-specific T-cell and B-cell responses, and reactogenicity. Results. Of the 66 participants, 40 previously received 2 doses ChAdOx1-S, 22 received 2 doses BNT162b2, and 4 received a single dose Ad26.COV2.S. The median age was 63 years (interquartile range [IQR], 60–66), 86% were male, and median CD4+ T-cell count was 650/μL (IQR, 423–941). The mean S1-specific antibody level increased from 35 binding antibody units (BAU)/ mL (95% confidence interval [CI], 24–46) to 4317 BAU/mL (95% CI, 3275–5360) (P < .0001). Of all participants, 97% showed an adequate response and the 45 antibody-negative participants all seroconverted. A significant increase in the proportion of PWH with ancestral S-specific CD4+ T cells (P = .04) and S-specific B cells (P = .02) was observed. Conclusions. An additional mRNA-1273 vaccination induced a robust serological response in 97% of PWH with a hyporesponse after primary vaccination.
KW - COVID-19
KW - HIV
KW - SARS-CoV-2 vaccines
KW - additional dose
KW - nonresponder
UR - http://www.scopus.com/inward/record.url?scp=85149183343&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/infdis/jiac451
DO - https://doi.org/10.1093/infdis/jiac451
M3 - Article
C2 - 36402141
SN - 0022-1899
VL - 227
SP - 651
EP - 662
JO - The Journal of Infectious Diseases
JF - The Journal of Infectious Diseases
IS - 5
ER -