TY - JOUR
T1 - Impact of clinical outcomes and imaging measures on health-related quality of life in secondary progressive MS
AU - W Koch, Marcus
AU - Mostert, Jop
AU - Repovic, Pavle
AU - Bowen, James D.
AU - Strijbis, Eva
AU - Uitdehaag, Bernard
AU - Cutter, Gary
N1 - Publisher Copyright: © The Author(s), 2021.
PY - 2021
Y1 - 2021
N2 - Background: Health-related quality of life (HRQOL) outcomes are often included as secondary outcomes in clinical trials in secondary progressive MS (SPMS), but little is known about the longitudinal association of HRQOL and clinical and imaging outcome measures in SPMS. Objective: To assess the association of change in clinical and imaging outcomes with HRQOL in people with SPMS. Methods: We used data from ASCEND, a large randomized controlled trial (n = 889), to investigate the association of significant worsening on the Expanded Disability Status Scale (EDSS), Timed 25 Foot Walk (T25FW), Nine Hole Peg Test (NHPT), Symbol Digit Modalities Test (SDMT), and change in lesional and volumetric imaging outcomes with significant worsening on the 36-Item Short Form Health Survey (SF-36) and the Multiple Sclerosis Impact Scale (MSIS-29) during 2 years of follow-up using logistic regression models. Results: HRQOL measures were most associated with EDSS and T25FW, less so with NHPT and SDMT, and not associated with lesional and volumetric imaging outcomes. Discussion: Worsening of the EDSS and T25FW was associated with two commonly used HRQOL measures. These outcomes therefore appear to be more patient relevant than either the NHPT or SDMT in the context of a 2-year clinical trial.
AB - Background: Health-related quality of life (HRQOL) outcomes are often included as secondary outcomes in clinical trials in secondary progressive MS (SPMS), but little is known about the longitudinal association of HRQOL and clinical and imaging outcome measures in SPMS. Objective: To assess the association of change in clinical and imaging outcomes with HRQOL in people with SPMS. Methods: We used data from ASCEND, a large randomized controlled trial (n = 889), to investigate the association of significant worsening on the Expanded Disability Status Scale (EDSS), Timed 25 Foot Walk (T25FW), Nine Hole Peg Test (NHPT), Symbol Digit Modalities Test (SDMT), and change in lesional and volumetric imaging outcomes with significant worsening on the 36-Item Short Form Health Survey (SF-36) and the Multiple Sclerosis Impact Scale (MSIS-29) during 2 years of follow-up using logistic regression models. Results: HRQOL measures were most associated with EDSS and T25FW, less so with NHPT and SDMT, and not associated with lesional and volumetric imaging outcomes. Discussion: Worsening of the EDSS and T25FW was associated with two commonly used HRQOL measures. These outcomes therefore appear to be more patient relevant than either the NHPT or SDMT in the context of a 2-year clinical trial.
KW - MRI
KW - Secondary progressive MS
KW - disability
KW - health-related quality of life
KW - outcome measures
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85122138923&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/34965774
UR - http://www.scopus.com/inward/record.url?scp=85122138923&partnerID=8YFLogxK
U2 - https://doi.org/10.1177/13524585211063623
DO - https://doi.org/10.1177/13524585211063623
M3 - Article
C2 - 34965774
SN - 1352-4585
JO - MULTIPLE SCLEROSIS JOURNAL
JF - MULTIPLE SCLEROSIS JOURNAL
ER -