Impact of Inflammation on Cognitive Functioning After Electroconvulsive Therapy in Older Patients with Depression with and Without White Matter Hyperintensities

Angela Carlier; Annemiek Dols; Mardien Oudega; Pascal Sienaert; Filip Bouckaert; Max L. Stek; Piet Eikelenboom; Eric van Exel; Didi Rhebergen

doi:https://doi.org/10.1016/j.jagp.2021.09.003

Impact of Inflammation on Cognitive Functioning After Electroconvulsive Therapy in Older Patients with Depression with and Without White Matter Hyperintensities

Angela Carlier, Annemiek Dols, Mardien Oudega, Pascal Sienaert, Filip Bouckaert, Max L. Stek, Piet Eikelenboom, Eric van Exel, Didi Rhebergen

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Objective: Should we treat older, patients with depression with white matter hyperintensities (WMH) with electroconvulsive therapy (ECT)? WMH, inflammation, depression and cognitive functioning are suggested to be intertwined. Hence, this study investigates whether the association between inflammation and cognition is different in patients with depression with or without WMH. Methods: Cognitive functioning was assessed using the Mini–Mental State Examination during and after a course of ECT in 77 older patients with depression. Serum samples (C–reactive protein [CRP], interleukin-6 [IL-6], interleukin-10 [IL-10] and tumour necrosis factor–alpha [TNF-α]) and 3T magnetic resonance imaging were obtained prior to ECT. Results: An interaction effect was found for IL-10, but not for CRP, IL-6 or TNF-α. Conclusion: In general, the association between inflammatory markers and cognition in patients with depression treated with ECT is not different in patients with WMH compared to patients without WMH.

Original language	English
Pages (from-to)	514-518
Number of pages	5
Journal	American Journal of Geriatric Psychiatry
Volume	30
Issue number	4
Early online date	16 Sept 2021
DOIs	https://doi.org/10.1016/j.jagp.2021.09.003 https://doi.org/10.1016/j.jagp.2021.09.003
Publication status	Published - Apr 2022

Keywords

Depression
cognition
cytokines
electroconvulsive therapy
hyperintensities
inflammation
white matter

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Carlier, A., Dols, A., Oudega, M., Sienaert, P., Bouckaert, F., Stek, M. L., Eikelenboom, P., van Exel, E., & Rhebergen, D. (2022). Impact of Inflammation on Cognitive Functioning After Electroconvulsive Therapy in Older Patients with Depression with and Without White Matter Hyperintensities. American Journal of Geriatric Psychiatry, 30(4), 514-518. https://doi.org/10.1016/j.jagp.2021.09.003, https://doi.org/10.1016/j.jagp.2021.09.003

@article{439a6efa8d5940fd8808972637304ccf,

title = "Impact of Inflammation on Cognitive Functioning After Electroconvulsive Therapy in Older Patients with Depression with and Without White Matter Hyperintensities",

abstract = "Objective: Should we treat older, patients with depression with white matter hyperintensities (WMH) with electroconvulsive therapy (ECT)? WMH, inflammation, depression and cognitive functioning are suggested to be intertwined. Hence, this study investigates whether the association between inflammation and cognition is different in patients with depression with or without WMH. Methods: Cognitive functioning was assessed using the Mini–Mental State Examination during and after a course of ECT in 77 older patients with depression. Serum samples (C–reactive protein [CRP], interleukin-6 [IL-6], interleukin-10 [IL-10] and tumour necrosis factor–alpha [TNF-α]) and 3T magnetic resonance imaging were obtained prior to ECT. Results: An interaction effect was found for IL-10, but not for CRP, IL-6 or TNF-α. Conclusion: In general, the association between inflammatory markers and cognition in patients with depression treated with ECT is not different in patients with WMH compared to patients without WMH.",

keywords = "Depression, cognition, cytokines, electroconvulsive therapy, hyperintensities, inflammation, white matter",

author = "Angela Carlier and Annemiek Dols and Mardien Oudega and Pascal Sienaert and Filip Bouckaert and Stek, {Max L.} and Piet Eikelenboom and {van Exel}, Eric and Didi Rhebergen",

note = "Funding Information: The authors report no conflicts with any concept discussed in this article. DR has received funding from ZonMW Programme ' Rational Pharmacotherapy' under grant agreement n°2016/15385/ZONMW . No conflicts of interest. Publisher Copyright: {\textcopyright} 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2022",

month = apr,

doi = "https://doi.org/10.1016/j.jagp.2021.09.003",

language = "English",

volume = "30",

pages = "514--518",

journal = "American Journal of Geriatric Psychiatry",

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Carlier, A, Dols, A , Oudega, M, Sienaert, P, Bouckaert, F, Stek, ML , Eikelenboom, P , van Exel, E & Rhebergen, D 2022, 'Impact of Inflammation on Cognitive Functioning After Electroconvulsive Therapy in Older Patients with Depression with and Without White Matter Hyperintensities', American Journal of Geriatric Psychiatry, vol. 30, no. 4, pp. 514-518. https://doi.org/10.1016/j.jagp.2021.09.003, https://doi.org/10.1016/j.jagp.2021.09.003

Impact of Inflammation on Cognitive Functioning After Electroconvulsive Therapy in Older Patients with Depression with and Without White Matter Hyperintensities. / Carlier, Angela; Dols, Annemiek ; Oudega, Mardien et al.
In: American Journal of Geriatric Psychiatry, Vol. 30, No. 4, 04.2022, p. 514-518.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Impact of Inflammation on Cognitive Functioning After Electroconvulsive Therapy in Older Patients with Depression with and Without White Matter Hyperintensities

AU - Carlier, Angela

AU - Dols, Annemiek

AU - Oudega, Mardien

AU - Sienaert, Pascal

AU - Bouckaert, Filip

AU - Stek, Max L.

AU - Eikelenboom, Piet

AU - van Exel, Eric

AU - Rhebergen, Didi

N1 - Funding Information: The authors report no conflicts with any concept discussed in this article. DR has received funding from ZonMW Programme ' Rational Pharmacotherapy' under grant agreement n°2016/15385/ZONMW . No conflicts of interest. Publisher Copyright: © 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2022/4

Y1 - 2022/4

N2 - Objective: Should we treat older, patients with depression with white matter hyperintensities (WMH) with electroconvulsive therapy (ECT)? WMH, inflammation, depression and cognitive functioning are suggested to be intertwined. Hence, this study investigates whether the association between inflammation and cognition is different in patients with depression with or without WMH. Methods: Cognitive functioning was assessed using the Mini–Mental State Examination during and after a course of ECT in 77 older patients with depression. Serum samples (C–reactive protein [CRP], interleukin-6 [IL-6], interleukin-10 [IL-10] and tumour necrosis factor–alpha [TNF-α]) and 3T magnetic resonance imaging were obtained prior to ECT. Results: An interaction effect was found for IL-10, but not for CRP, IL-6 or TNF-α. Conclusion: In general, the association between inflammatory markers and cognition in patients with depression treated with ECT is not different in patients with WMH compared to patients without WMH.

AB - Objective: Should we treat older, patients with depression with white matter hyperintensities (WMH) with electroconvulsive therapy (ECT)? WMH, inflammation, depression and cognitive functioning are suggested to be intertwined. Hence, this study investigates whether the association between inflammation and cognition is different in patients with depression with or without WMH. Methods: Cognitive functioning was assessed using the Mini–Mental State Examination during and after a course of ECT in 77 older patients with depression. Serum samples (C–reactive protein [CRP], interleukin-6 [IL-6], interleukin-10 [IL-10] and tumour necrosis factor–alpha [TNF-α]) and 3T magnetic resonance imaging were obtained prior to ECT. Results: An interaction effect was found for IL-10, but not for CRP, IL-6 or TNF-α. Conclusion: In general, the association between inflammatory markers and cognition in patients with depression treated with ECT is not different in patients with WMH compared to patients without WMH.

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KW - cognition

KW - cytokines

KW - electroconvulsive therapy

KW - hyperintensities

KW - inflammation

KW - white matter

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U2 - https://doi.org/10.1016/j.jagp.2021.09.003

DO - https://doi.org/10.1016/j.jagp.2021.09.003

M3 - Article

C2 - 34629222

SN - 1064-7481

VL - 30

SP - 514

EP - 518

JO - American Journal of Geriatric Psychiatry

JF - American Journal of Geriatric Psychiatry

IS - 4

ER -

Carlier A, Dols A , Oudega M, Sienaert P, Bouckaert F, Stek ML et al. Impact of Inflammation on Cognitive Functioning After Electroconvulsive Therapy in Older Patients with Depression with and Without White Matter Hyperintensities. American Journal of Geriatric Psychiatry. 2022 Apr;30(4):514-518. Epub 2021 Sept 16. doi: https://doi.org/10.1016/j.jagp.2021.09.003, https://doi.org/10.1016/j.jagp.2021.09.003

Impact of Inflammation on Cognitive Functioning After Electroconvulsive Therapy in Older Patients with Depression with and Without White Matter Hyperintensities

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