Impact of New Scatter Correction Strategies on High-Resolution Research Tomograph Brain PET Studies

Syahir Mansor, Ronald Boellaard, Marc C. Huisman, Bart N. M. van Berckel, Robert C. Schuit, Albert D. Windhorst, Adriaan A. Lammertsma, Floris H. P. van Velden

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Purpose The aim of this study is to evaluate the impact of different scatter correction strategies on quantification of high-resolution research tomograph (HRRT) data for three tracers covering a wide range in kinetic profiles. Procedures Healthy subjects received dynamic HRRT scans using either (R)-[11C]verapamil (n = 5), [11C]raclopride (n = 5) or [11C]flumazenil (n = 5). To reduce the effects of patient motion on scatter scaling factors, a margin in the attenuation correction factor (ACF) sinogram was applied prior to 2D or 3D single scatter simulation (SSS). Results Some (R)-[11C]verapamil studies showed prominent artefacts that disappeared with an ACF-margin of 10 mm or more. Use of 3D SSS for (R)-[11C]verapamil showed a statistically significant increase in volume of distribution compared with 2D SSS (p < 0.05), but not for [11C]raclopride and [11C]flumazenil studies (p > 0.05). Conclusions When there is a patient motion-induced mismatch between transmission and emission scans, applying an ACF-margin resulted in more reliable scatter scaling factors but did not change (and/or deteriorate) quantification.
Original languageEnglish
Pages (from-to)627-635
JournalMolecular Imaging and Biology
Issue number4
Publication statusPublished - Aug 2016


  • ACF-margin
  • High-resolution research tomograph (HRRT)
  • Patient motion
  • Positron emission tomography (PET)
  • Scatter correction
  • Scatter scaling factor
  • Single scatter simulation

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