TY - JOUR
T1 - Impaired Set-Shifting from Dorsal Stream Disconnection
T2 - Insights from a European Series of Right Parietal Lower-Grade Glioma Resection
AU - Hartung, Suzanne L
AU - Mandonnet, Emmanuel
AU - de Witt Hamer, Philip
AU - Klein, Martin
AU - Wager, Michel
AU - Rech, Fabien
AU - Pallud, Johan
AU - Pessanha Viegas, Catarina
AU - Ille, Sebastian
AU - Krieg, Sandro M
AU - Robe, Pierre A
AU - van Zandvoort, Martine J E
N1 - Funding Information: We thank all the contributing centres across Europe for the collaboration and their support. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Awake surgery with cognitive monitoring has increasingly been implemented to preserve brain networks and functionality. More recently, not only surgery in the left but also in the right hemisphere, i.c., the parietal lobe, was associated with potential risk for deficits in cognitive functions, such as cognitive flexibility. In this explorative pilot study, we compare cognitive performance more than three months after surgery with baseline measurements and explore the association between cognitive decline and subcortical tracts that may have been severed during surgery in the right hemisphere. Twenty-two patients who underwent surgery for a right parietal low-grade glioma were assessed pre- and postoperatively using the Trail Making Test and the Stroop task to administer set-shifting abilities and inhibition. Volume measurements and lesion-symptom mapping analyses were performed on postoperative MRI scans. Careful interpretation of the results shows a change in TMT performance and not on the Stroop Task when the lateral part of the arcuate fasciculus is damaged, indicating that disconnection of the lateral part of the dorsal stream might be correlated specifically with impaired set-shifting and not with inhibition. More importantly, this study underlines the need for international concertation to allow larger studies to increase power and perform more detailed analyses.
AB - Awake surgery with cognitive monitoring has increasingly been implemented to preserve brain networks and functionality. More recently, not only surgery in the left but also in the right hemisphere, i.c., the parietal lobe, was associated with potential risk for deficits in cognitive functions, such as cognitive flexibility. In this explorative pilot study, we compare cognitive performance more than three months after surgery with baseline measurements and explore the association between cognitive decline and subcortical tracts that may have been severed during surgery in the right hemisphere. Twenty-two patients who underwent surgery for a right parietal low-grade glioma were assessed pre- and postoperatively using the Trail Making Test and the Stroop task to administer set-shifting abilities and inhibition. Volume measurements and lesion-symptom mapping analyses were performed on postoperative MRI scans. Careful interpretation of the results shows a change in TMT performance and not on the Stroop Task when the lateral part of the arcuate fasciculus is damaged, indicating that disconnection of the lateral part of the dorsal stream might be correlated specifically with impaired set-shifting and not with inhibition. More importantly, this study underlines the need for international concertation to allow larger studies to increase power and perform more detailed analyses.
KW - Brain network
KW - Cognitive flexibility executive function
KW - Connectivity
KW - Glioma
KW - Intraoperative monitoring
KW - Trail Making Test
UR - http://www.scopus.com/inward/record.url?scp=85121407620&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/cancers13133337
DO - https://doi.org/10.3390/cancers13133337
M3 - Article
C2 - 34283043
SN - 2072-6694
VL - 13
JO - Cancers
JF - Cancers
IS - 13
M1 - 3337
ER -