Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy

Gerty Schreibelt, Kalijn F. Bol, Erik H. J. G. Aarntzen, Winald R. Gerritsen, Cornelis J. A. Punt, Carl G. Figdor, I. Jolanda M. de Vries

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11 Citations (Scopus)

Abstract

Dendritic cell-based anticancer immunotherapy is feasible, safe and results in the induction of tumor-specific immune responses, at least in a fraction of vaccinated patients. The concomitant activation of cytotoxic and helper T cells, by loading DCs with peptides or electroporating them with the corresponding mRNAs, may further enhance vaccine-induced antitumor responses
Original languageEnglish
Pages (from-to)e24440
JournalOncoimmunology
Volume2
Issue number6
DOIs
Publication statusPublished - 2013

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