Impulsive-like behavior in differential-reinforcement-of-low-rate 36 s responding in mice depends on training history

Tommy Pattij, Laus M. Broersen, Stefanie Peter, Berend Olivier

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14 Citations (Scopus)


Prior behavioral history in operant conditioning paradigms may induce impulsive-like responding as shown in rats. Little is known to what extent behavioral history influences subsequent behavior in mice, therefore the present study investigated the effects of lever-pressing under a fixed-ratio 5 schedule of reinforcement on subsequent differential-reinforcement-of-low-rate (DRL) 36 s performance in wild type mice compared to the behavior of 5-HT 1B receptor knockout mice. Acquisition of both autoshaping and fixed-ratio 5 training was faster in 5-HT1B receptor knockout compared to wild type mice. Nevertheless, in the DRL 36 s procedure no differences were observed between genotypes. Both wild type and 5-HT 1B receptor knockout mice displayed premature or impulsive-like responding in the DRL 36 s procedure, for example a peak location of responses around 20 s and high rates of responding. Taken together, the present data suggest that impulsive-like responding in the DRL 36 s procedure in mice depends on prior behavioral history.

Original languageEnglish
Pages (from-to)169-171
Number of pages3
JournalNeuroscience letters
Issue number2
Publication statusPublished - 9 Jan 2004


  • 5-HT receptor knockout mice
  • Differential-reinforcement-of-low-rate
  • Discrimination learning
  • Fixed-ratio 5
  • Impulsivity
  • Operant conditioning

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