TY - JOUR
T1 - Impulsive-like behavior in differential-reinforcement-of-low-rate 36 s responding in mice depends on training history
AU - Pattij, Tommy
AU - Broersen, Laus M.
AU - Peter, Stefanie
AU - Olivier, Berend
PY - 2004/1/9
Y1 - 2004/1/9
N2 - Prior behavioral history in operant conditioning paradigms may induce impulsive-like responding as shown in rats. Little is known to what extent behavioral history influences subsequent behavior in mice, therefore the present study investigated the effects of lever-pressing under a fixed-ratio 5 schedule of reinforcement on subsequent differential-reinforcement-of-low-rate (DRL) 36 s performance in wild type mice compared to the behavior of 5-HT 1B receptor knockout mice. Acquisition of both autoshaping and fixed-ratio 5 training was faster in 5-HT1B receptor knockout compared to wild type mice. Nevertheless, in the DRL 36 s procedure no differences were observed between genotypes. Both wild type and 5-HT 1B receptor knockout mice displayed premature or impulsive-like responding in the DRL 36 s procedure, for example a peak location of responses around 20 s and high rates of responding. Taken together, the present data suggest that impulsive-like responding in the DRL 36 s procedure in mice depends on prior behavioral history.
AB - Prior behavioral history in operant conditioning paradigms may induce impulsive-like responding as shown in rats. Little is known to what extent behavioral history influences subsequent behavior in mice, therefore the present study investigated the effects of lever-pressing under a fixed-ratio 5 schedule of reinforcement on subsequent differential-reinforcement-of-low-rate (DRL) 36 s performance in wild type mice compared to the behavior of 5-HT 1B receptor knockout mice. Acquisition of both autoshaping and fixed-ratio 5 training was faster in 5-HT1B receptor knockout compared to wild type mice. Nevertheless, in the DRL 36 s procedure no differences were observed between genotypes. Both wild type and 5-HT 1B receptor knockout mice displayed premature or impulsive-like responding in the DRL 36 s procedure, for example a peak location of responses around 20 s and high rates of responding. Taken together, the present data suggest that impulsive-like responding in the DRL 36 s procedure in mice depends on prior behavioral history.
KW - 5-HT receptor knockout mice
KW - Differential-reinforcement-of-low-rate
KW - Discrimination learning
KW - Fixed-ratio 5
KW - Impulsivity
KW - Operant conditioning
UR - http://www.scopus.com/inward/record.url?scp=0347418187&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neulet.2003.10.004
DO - https://doi.org/10.1016/j.neulet.2003.10.004
M3 - Article
C2 - 14698465
SN - 0304-3940
VL - 354
SP - 169
EP - 171
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -