TY - JOUR
T1 - In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves
AU - Uiterwijk, Marcelle
AU - Smits, Anthal I. P. M.
AU - van Geemen, Daphne
AU - van Klarenbosch, Bas
AU - Dekker, Sylvia
AU - Cramer, Maarten Jan
AU - van Rijswijk, Jan Willem
AU - Lurier, Emily B.
AU - di Luca, Andrea
AU - Brugmans, Marieke C. P.
AU - Mes, Tristan
AU - Bosman, Anton W.
AU - Aikawa, Elena
AU - Gründeman, Paul F.
AU - Bouten, Carlijn V. C.
AU - Kluin, Jolanda
PY - 2020/12/1
Y1 - 2020/12/1
N2 - In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random or circumferentially aligned fibers, after 12 months of implantation in sheep. These unexpected findings and the observed intervalvular variability highlight the need for a mechanistic understanding of the long-term in situ remodeling processes in large animal models to improve predictability of outcome toward robust and safe clinical application.
AB - In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random or circumferentially aligned fibers, after 12 months of implantation in sheep. These unexpected findings and the observed intervalvular variability highlight the need for a mechanistic understanding of the long-term in situ remodeling processes in large animal models to improve predictability of outcome toward robust and safe clinical application.
KW - cell biology/structural biology
KW - valvular heart disease
UR - http://www.scopus.com/inward/record.url?scp=85097461379&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jacbts.2020.09.011
DO - https://doi.org/10.1016/j.jacbts.2020.09.011
M3 - Article
C2 - 33426376
SN - 2452-302X
VL - 5
SP - 1187
EP - 1206
JO - JACC. Basic to translational science
JF - JACC. Basic to translational science
IS - 12
ER -