In Vitro Meiosis of Male Germline Stem Cells

Qijing Lei, Xin Lai, Jitske Eliveld, Susana M. Chuva de Sousa Lopes, Ans M. M. van Pelt, Geert Hamer

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)


In this article, Hamer and colleagues show that, on a feeder layer of Sertoli cells, mouse spermatogonial stem cells can be induced to undergo meiosis in vitro. However, meiotic recombination and checkpoints do not necessarily function properly in vitro, and the authors warn that in vitro-generated spermatid-like cells should be thoroughly analyzed before clinical application can be considered.
Original languageEnglish
Pages (from-to)1140-1153
Number of pages14
JournalStem cell reports
Issue number5
Publication statusPublished - 10 Nov 2020


  • Sertoli cell lines
  • in vitro spermatogenesis
  • meiosis
  • meiotic checkpoints
  • spermatogonial stem cells

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