In vivo animal functional MRI: Improved image quality with a body-adapted mold

Willy Landuyt, Stefan Sunaert, Davide Farina, Martijn Meijerink, Eric Béatse, Paul Van Hecke, Robert Hermans, Guy Marchal, Philippe Lambin, Hilde Bosmans

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13 Citations (Scopus)


Purpose: To reduce functional magnetic resonance imaging (fMRI) susceptibility distortion at the air/tissue interphase in animal experiments. Materials and Methods: We investigated the applicability of a body-adaptable flexible mold consisting of a fast-setting alginate. This technique was implemented for subcutaneous growing tumors in rats and for the brains of monkeys. Results: The T2*-weighted gradient-echo, echo-planar imaging (GE-EPI) data obtained with the body-adapted mold showed a reduction of susceptibility artifacts and improved image quality. With both rat tumor and monkey brain, an optimized match with the anatomical T1 images was possible. Conclusion: The present mold methodology is a rapid, easy, and inexpensive way to reduce magnetic susceptibility during animal GE-EPI.

Original languageEnglish
Pages (from-to)224-227
Number of pages4
JournalJournal of magnetic resonance imaging
Issue number2
Publication statusPublished - 1 Jan 2002


  • BOLD effect
  • Brain function
  • Functional MRI
  • Image distortion
  • Susceptibility

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