In vivo animal functional MRI: Improved image quality with a body-adapted mold

Willy Landuyt; Stefan Sunaert; Davide Farina; Martijn Meijerink; Eric Béatse; Paul Van Hecke; Robert Hermans; Guy Marchal; Philippe Lambin; Hilde Bosmans

doi:https://doi.org/10.1002/jmri.10144

In vivo animal functional MRI: Improved image quality with a body-adapted mold

Willy Landuyt, Stefan Sunaert, Davide Farina, Martijn Meijerink, Eric Béatse, Paul Van Hecke, Robert Hermans, Guy Marchal, Philippe Lambin, Hilde Bosmans

Radiology and Nuclear Medicine (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

Purpose: To reduce functional magnetic resonance imaging (fMRI) susceptibility distortion at the air/tissue interphase in animal experiments. Materials and Methods: We investigated the applicability of a body-adaptable flexible mold consisting of a fast-setting alginate. This technique was implemented for subcutaneous growing tumors in rats and for the brains of monkeys. Results: The T₂*-weighted gradient-echo, echo-planar imaging (GE-EPI) data obtained with the body-adapted mold showed a reduction of susceptibility artifacts and improved image quality. With both rat tumor and monkey brain, an optimized match with the anatomical T₁ images was possible. Conclusion: The present mold methodology is a rapid, easy, and inexpensive way to reduce magnetic susceptibility during animal GE-EPI.

Original language	English
Pages (from-to)	224-227
Number of pages	4
Journal	Journal of magnetic resonance imaging
Volume	16
Issue number	2
DOIs	https://doi.org/10.1002/jmri.10144
Publication status	Published - 1 Jan 2002

Keywords

BOLD effect
Brain function
Functional MRI
Image distortion
Susceptibility

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https://doi.org/10.1002/jmri.10144

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title = "In vivo animal functional MRI: Improved image quality with a body-adapted mold",

abstract = "Purpose: To reduce functional magnetic resonance imaging (fMRI) susceptibility distortion at the air/tissue interphase in animal experiments. Materials and Methods: We investigated the applicability of a body-adaptable flexible mold consisting of a fast-setting alginate. This technique was implemented for subcutaneous growing tumors in rats and for the brains of monkeys. Results: The T2*-weighted gradient-echo, echo-planar imaging (GE-EPI) data obtained with the body-adapted mold showed a reduction of susceptibility artifacts and improved image quality. With both rat tumor and monkey brain, an optimized match with the anatomical T1 images was possible. Conclusion: The present mold methodology is a rapid, easy, and inexpensive way to reduce magnetic susceptibility during animal GE-EPI.",

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author = "Willy Landuyt and Stefan Sunaert and Davide Farina and Martijn Meijerink and Eric B{\'e}atse and {Van Hecke}, Paul and Robert Hermans and Guy Marchal and Philippe Lambin and Hilde Bosmans",

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T1 - In vivo animal functional MRI

T2 - Improved image quality with a body-adapted mold

AU - Landuyt, Willy

AU - Sunaert, Stefan

AU - Farina, Davide

AU - Meijerink, Martijn

AU - Béatse, Eric

AU - Van Hecke, Paul

AU - Hermans, Robert

AU - Marchal, Guy

AU - Lambin, Philippe

AU - Bosmans, Hilde

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N2 - Purpose: To reduce functional magnetic resonance imaging (fMRI) susceptibility distortion at the air/tissue interphase in animal experiments. Materials and Methods: We investigated the applicability of a body-adaptable flexible mold consisting of a fast-setting alginate. This technique was implemented for subcutaneous growing tumors in rats and for the brains of monkeys. Results: The T2*-weighted gradient-echo, echo-planar imaging (GE-EPI) data obtained with the body-adapted mold showed a reduction of susceptibility artifacts and improved image quality. With both rat tumor and monkey brain, an optimized match with the anatomical T1 images was possible. Conclusion: The present mold methodology is a rapid, easy, and inexpensive way to reduce magnetic susceptibility during animal GE-EPI.

AB - Purpose: To reduce functional magnetic resonance imaging (fMRI) susceptibility distortion at the air/tissue interphase in animal experiments. Materials and Methods: We investigated the applicability of a body-adaptable flexible mold consisting of a fast-setting alginate. This technique was implemented for subcutaneous growing tumors in rats and for the brains of monkeys. Results: The T2*-weighted gradient-echo, echo-planar imaging (GE-EPI) data obtained with the body-adapted mold showed a reduction of susceptibility artifacts and improved image quality. With both rat tumor and monkey brain, an optimized match with the anatomical T1 images was possible. Conclusion: The present mold methodology is a rapid, easy, and inexpensive way to reduce magnetic susceptibility during animal GE-EPI.

KW - BOLD effect

KW - Brain function

KW - Functional MRI

KW - Image distortion

KW - Susceptibility

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In vivo animal functional MRI: Improved image quality with a body-adapted mold

Abstract

Keywords

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