TY - JOUR
T1 - In vivo (R)-[(11)C]PK11195 PET imaging of 18kDa translocator protein in recent onset psychosis
AU - Van Der Doef, Thalia F.
AU - De Witte, Lot D.
AU - Sutterland, Arjen L.
AU - Jobse, Ellen
AU - Yaqub, Maqsood
AU - Boellaard, Ronald
AU - De Haan, Lieuwe
AU - Eriksson, Jonas
AU - Lammertsma, Adriaan A.
AU - Kahn, René S.
AU - Van Berckel, Bart N.M.
PY - 2016/8/31
Y1 - 2016/8/31
N2 - Evidence is accumulating that immune dysfunction is involved in the pathophysiology of schizophrenia. It has been hypothesized that microglia activation is present in patients with schizophrenia. Various in vivo and post-mortem studies have investigated this hypothesis, but as yet with inconclusive results. Microglia activation is associated with elevations in 18 kDa translocator protein (TSPO) levels, which can be measured with the positron emission tomography (PET) tracer (R)-[(11)C]PK11195. The purpose of the present study was to investigate microglia activation in psychosis in vivo at an early stage of the disease. (R)-[(11)C]PK11195 binding potential (BPND) was measured in 19 patients with recent onset psychosis and 17 age and gender-matched healthy controls. Total gray matter, as well as five gray matter regions of interest (frontal cortex, temporal cortex, parietal cortex, striatum, and thalamus) were defined a priori. PET data were analysed using a reference tissue approach and a supervised cluster analysis algorithm to identify the reference region. No significant difference in (R)-[(11)C]PK11195 BPND between patients and controls was found in total gray matter, nor one of the regions of interest. These findings suggest that microglia activation is not present in recent onset psychosis or that it is a subtle phenomenon that could not be detected using the design of the present study.
AB - Evidence is accumulating that immune dysfunction is involved in the pathophysiology of schizophrenia. It has been hypothesized that microglia activation is present in patients with schizophrenia. Various in vivo and post-mortem studies have investigated this hypothesis, but as yet with inconclusive results. Microglia activation is associated with elevations in 18 kDa translocator protein (TSPO) levels, which can be measured with the positron emission tomography (PET) tracer (R)-[(11)C]PK11195. The purpose of the present study was to investigate microglia activation in psychosis in vivo at an early stage of the disease. (R)-[(11)C]PK11195 binding potential (BPND) was measured in 19 patients with recent onset psychosis and 17 age and gender-matched healthy controls. Total gray matter, as well as five gray matter regions of interest (frontal cortex, temporal cortex, parietal cortex, striatum, and thalamus) were defined a priori. PET data were analysed using a reference tissue approach and a supervised cluster analysis algorithm to identify the reference region. No significant difference in (R)-[(11)C]PK11195 BPND between patients and controls was found in total gray matter, nor one of the regions of interest. These findings suggest that microglia activation is not present in recent onset psychosis or that it is a subtle phenomenon that could not be detected using the design of the present study.
KW - Journal Article
UR - http://www.scopus.com/inward/record.url?scp=85011861222&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/npjschz.2016.31
DO - https://doi.org/10.1038/npjschz.2016.31
M3 - Article
C2 - 27602389
SN - 0920-9964
VL - 2
SP - 16031
JO - Schizophrenia research
JF - Schizophrenia research
M1 - 16031
ER -