TY - JOUR
T1 - Incidence, causes, and outcomes of out-of-hospital cardiac arrest in children
T2 - A comprehensive, prospective, population-based study in the netherlands
AU - Bardai, Abdennasser
AU - Berdowski, Jocelyn
AU - Van Der Werf, Christian
AU - Blom, Marieke T.
AU - Ceelen, Manon
AU - Van Langen, Irene M.
AU - Tijssen, Jan G.P.
AU - Wilde, Arthur A.M.
AU - Koster, Rudolph W.
AU - Tan, Hanno L.
N1 - Funding Information: Dr. Bardai was supported by the Netherlands Organization for Scientific Research (NWO, grant Mozaiek 017.003.084 ). Drs. Wilde and van Langen were supported by Zorg Onderzoek Nederland Medische Wetenschappen (Zon-MW, grant 120610013 ). Dr. Wilde was supported by Fondation Leducq Trans-Atlantic Network of Excellence, Preventing Sudden Death (grant 05-CVD-01 ). Dr. Koster was supported by the Netherlands Heart Foundation (grant 2006B179 ) and Physio Control, Inc . Dr. Tan was supported by the Netherlands Organization for Scientific Research (NWO, grant ZonMW Vici 918.86.616 ) and the Dutch Medicines Evaluation Board (MEB/CBG). All other authors have reported that they have no relationships to disclose. Drs. Bardai, Berdowski, and van der Werf contributed equally to this work.
PY - 2011/5/3
Y1 - 2011/5/3
N2 - Objectives: This study sought to determine comprehensively the incidence of pediatric out-of-hospital cardiac arrest (OHCA) and its contribution to total pediatric mortality, the causes of pediatric OHCA, and the outcome of resuscitation of pediatric OHCA patients. Background: There is a paucity of complete studies on incidence, causes, and outcomes of pediatric OHCA. Methods: In this prospective, population-based study, OHCA victims younger than age 21 years in 1 province of the Netherlands were registered through both emergency medical services and coroners over a period of 4.3 years. Death certificate data on total pediatric mortality, survival status, and neurological outcome at hospital discharge also were obtained. Results: With a total mortality of 923 during the study period and 233 victims of OHCA (including 221 who died and 12 who survived), OHCA caused 24% (221 of 923) of total pediatric mortality. Natural causes of OHCA amounted to 115 (49%) cases, with cardiac causes being most prevalent (n = 90, 39%). The incidence of pediatric OHCA was 9.0 per 100,000 pediatric person-years (95% confidence interval: 7.8 to 10.3), whereas the incidence of pediatric OHCA from cardiac causes was 3.2 (95% confidence interval: 2.5 to 3.9). Of 51 resuscitated patients, 12 (24%) survived; among survivors, 10 (83%) had a neurologically intact outcome. Conclusions: Out-of-hospital cardiac arrest accounts for a significant proportion of pediatric mortality, and cardiac causes are the most prevalent causes of OHCA. The vast majority of OHCA survivors have a neurologically intact outcome.
AB - Objectives: This study sought to determine comprehensively the incidence of pediatric out-of-hospital cardiac arrest (OHCA) and its contribution to total pediatric mortality, the causes of pediatric OHCA, and the outcome of resuscitation of pediatric OHCA patients. Background: There is a paucity of complete studies on incidence, causes, and outcomes of pediatric OHCA. Methods: In this prospective, population-based study, OHCA victims younger than age 21 years in 1 province of the Netherlands were registered through both emergency medical services and coroners over a period of 4.3 years. Death certificate data on total pediatric mortality, survival status, and neurological outcome at hospital discharge also were obtained. Results: With a total mortality of 923 during the study period and 233 victims of OHCA (including 221 who died and 12 who survived), OHCA caused 24% (221 of 923) of total pediatric mortality. Natural causes of OHCA amounted to 115 (49%) cases, with cardiac causes being most prevalent (n = 90, 39%). The incidence of pediatric OHCA was 9.0 per 100,000 pediatric person-years (95% confidence interval: 7.8 to 10.3), whereas the incidence of pediatric OHCA from cardiac causes was 3.2 (95% confidence interval: 2.5 to 3.9). Of 51 resuscitated patients, 12 (24%) survived; among survivors, 10 (83%) had a neurologically intact outcome. Conclusions: Out-of-hospital cardiac arrest accounts for a significant proportion of pediatric mortality, and cardiac causes are the most prevalent causes of OHCA. The vast majority of OHCA survivors have a neurologically intact outcome.
KW - cardiopulmonary resuscitation
KW - children
KW - epidemiology
KW - out-of-hospital cardiac arrest
UR - http://www.scopus.com/inward/record.url?scp=79955435591&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jacc.2010.11.054
DO - https://doi.org/10.1016/j.jacc.2010.11.054
M3 - Article
C2 - 21527156
SN - 0735-1097
VL - 57
SP - 1822
EP - 1828
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 18
ER -